@article{94355f66be5849469a5d9855cfec4761,
title = "Chronic Inflammation Directs an Olfactory Stem Cell Functional Switch from Neuroregeneration to Immune Defense",
abstract = "Chen et al. identify the immune function of long-lived olfactory stem cells to regulate inflammatory cell recruitment and local proliferation by releasing cytokines and chemokines. Chronically activated stem cells shut down regenerative function and signal macrophages to maintain epithelial immune defense.",
keywords = "NF-kB, basal stem cell, chemokine, chronic inflammation, neural stem cell, neurogenesis, olfactory epithelium, regeneration",
author = "Mengfei Chen and Reed, {Randall R.} and Lane, {Andrew P.}",
note = "Funding Information: We thank Liliana Florea and Corina Antonescu (Johns Hopkins School of Medicine) for assistance in RNA-seq data analysis, Hao Zhang (Bloomberg School of Public Health, JHU) for FACS, and the Center for Sensory Biology imaging core facility. This work was funded by National Institutes of Health (NIH) grants R01 DC016106, R01 AI132590 (A.P.L.), and R01 DC004553 (R.R.R). M.C. is supported by the National Natural Science Foundation of China (81200684). M.C. and A.P.L. designed research; M.C. performed research; M.C. R.R.R. and A.P.L. analyzed data; and M.C. R.R.R. and A.P.L. wrote the paper. The authors declare no competing interests. Funding Information: We thank Liliana Florea and Corina Antonescu (Johns Hopkins School of Medicine) for assistance in RNA-seq data analysis, Hao Zhang (Bloomberg School of Public Health, JHU) for FACS, and the Center for Sensory Biology imaging core facility. This work was funded by National Institutes of Health (NIH) grants R01 DC016106 , R01 AI132590 (A.P.L.), and R01 DC004553 (R.R.R). M.C. is supported by the National Natural Science Foundation of China (81200684). Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",
year = "2019",
month = oct,
day = "3",
doi = "10.1016/j.stem.2019.08.011",
language = "English (US)",
volume = "25",
pages = "501--513.e5",
journal = "Cell stem cell",
issn = "1934-5909",
publisher = "Cell Press",
number = "4",
}