Chronic Inflammation Directs an Olfactory Stem Cell Functional Switch from Neuroregeneration to Immune Defense

Research output: Contribution to journalArticlepeer-review

Abstract

Chen et al. identify the immune function of long-lived olfactory stem cells to regulate inflammatory cell recruitment and local proliferation by releasing cytokines and chemokines. Chronically activated stem cells shut down regenerative function and signal macrophages to maintain epithelial immune defense.

Original languageEnglish (US)
Pages (from-to)501-513.e5
JournalCell stem cell
Volume25
Issue number4
DOIs
StatePublished - Oct 3 2019

Keywords

  • NF-kB
  • basal stem cell
  • chemokine
  • chronic inflammation
  • neural stem cell
  • neurogenesis
  • olfactory epithelium
  • regeneration

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Cell Biology

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