Chronic Immune Thrombocytopenic Purpura in Monozygotic Twins: Genetic Factors Predisposing to ITP

Andrew J. Laster, C. Lockard Conley, Thomas S. Kickler, Carole A. Dorsch, Wilma B. Bias

Research output: Contribution to journalArticlepeer-review

Abstract

Chronic immune thrombocytopenic purpura (ITP) appeared in monozygotic twin girls during adolescence. An older sister was discovered to have less severe thrombocytopenia without purpura. Increased amounts of platelet-associated immunoglobulin were detected in the proband and her sisters but in no other members of the family. Antibodies reacting with nuclear components were demonstrated in the serum of the three sisters, both parents, and other members of the kindred, some of whom had immunologically mediated clinical disorders. These observations add to the increasing evidence that a genetically determined disorder of immune regulation is often a factor predisposing to chronic ITP. The Kindred.

Original languageEnglish (US)
Pages (from-to)1495-1498
Number of pages4
JournalNew England Journal of Medicine
Volume307
Issue number24
DOIs
StatePublished - Dec 9 1982

ASJC Scopus subject areas

  • Medicine(all)

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