Chronic hypoxemia causes extracellular glutamate concentration to increase in the cerebral cortex of the near-term fetal sheep

Janice L. Henderson, James D. Reynolds, Franklin Dexter, Barry Atkins, Jim Hrdy, Dan Poduska, Donald H. Penning

Research output: Contribution to journalArticle

Abstract

Fetal hypoxia is an important cause of neurologic morbidity and mortality. Hypoxia-induced increase in extracellular glutamate concentration can lead to excitotoxic neuronal death in adults. The objective of this study was to test whether chronic fetal hypoxemia increases extracellular glutamate concentration in the unanesthetized intact cerebral cortex of the near-term fetal sheep. Microdialysis probes were implanted into the parasagittal parietal cortex and periventricular white matter of near-term fetal sheep. At 124 ± 1 days of gestation, extracellular glutamate concentration was determined before and during 24 h of fetal hypoxemia. Chronic hypoxemia was produced by tightening a vascular occluder placed around the maternal common iliac artery. Larger decreases in fetal arterial oxygen content were associated with larger increases in extracellular glutamate concentration in the parietal cortex (Kendall's τ = 0.81, N = 7, p = 0.005). No such relationship was detected in the periventricular white matter. Chronic hypoxemia increases extracellular glutamate concentration in the intact cerebral cortex of the unanesthetized near-term fetal sheep.

Original languageEnglish (US)
Pages (from-to)287-293
Number of pages7
JournalDevelopmental Brain Research
Volume105
Issue number2
DOIs
StatePublished - Feb 10 1998
Externally publishedYes

Keywords

  • Cerebral cortex
  • Glutamate
  • Hypoxia
  • Microdialysis
  • Ovine fetus
  • Periventricular white matter

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology

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