Chronic hypoxemia causes extracellular glutamate concentration to increase in the cerebral cortex of the near-term fetal sheep

Janice L Henderson, James D. Reynolds, Franklin Dexter, Barry Atkins, Jim Hrdy, Dan Poduska, Donald H. Penning

Research output: Contribution to journalArticle

Abstract

Fetal hypoxia is an important cause of neurologic morbidity and mortality. Hypoxia-induced increase in extracellular glutamate concentration can lead to excitotoxic neuronal death in adults. The objective of this study was to test whether chronic fetal hypoxemia increases extracellular glutamate concentration in the unanesthetized intact cerebral cortex of the near-term fetal sheep. Microdialysis probes were implanted into the parasagittal parietal cortex and periventricular white matter of near-term fetal sheep. At 124 ± 1 days of gestation, extracellular glutamate concentration was determined before and during 24 h of fetal hypoxemia. Chronic hypoxemia was produced by tightening a vascular occluder placed around the maternal common iliac artery. Larger decreases in fetal arterial oxygen content were associated with larger increases in extracellular glutamate concentration in the parietal cortex (Kendall's τ = 0.81, N = 7, p = 0.005). No such relationship was detected in the periventricular white matter. Chronic hypoxemia increases extracellular glutamate concentration in the intact cerebral cortex of the unanesthetized near-term fetal sheep.

Original languageEnglish (US)
Pages (from-to)287-293
Number of pages7
JournalDevelopmental Brain Research
Volume105
Issue number2
DOIs
StatePublished - Feb 10 1998
Externally publishedYes

Fingerprint

Cerebral Cortex
Glutamic Acid
Sheep
Parietal Lobe
Fetal Hypoxia
Iliac Artery
Microdialysis
Nervous System
Blood Vessels
Mothers
Hypoxia
Oxygen
Morbidity
Pregnancy
Mortality
White Matter

Keywords

  • Cerebral cortex
  • Glutamate
  • Hypoxia
  • Microdialysis
  • Ovine fetus
  • Periventricular white matter

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

Cite this

Chronic hypoxemia causes extracellular glutamate concentration to increase in the cerebral cortex of the near-term fetal sheep. / Henderson, Janice L; Reynolds, James D.; Dexter, Franklin; Atkins, Barry; Hrdy, Jim; Poduska, Dan; Penning, Donald H.

In: Developmental Brain Research, Vol. 105, No. 2, 10.02.1998, p. 287-293.

Research output: Contribution to journalArticle

Henderson, Janice L ; Reynolds, James D. ; Dexter, Franklin ; Atkins, Barry ; Hrdy, Jim ; Poduska, Dan ; Penning, Donald H. / Chronic hypoxemia causes extracellular glutamate concentration to increase in the cerebral cortex of the near-term fetal sheep. In: Developmental Brain Research. 1998 ; Vol. 105, No. 2. pp. 287-293.
@article{4c8dfdda1c9b480892bbeb704cf1ad98,
title = "Chronic hypoxemia causes extracellular glutamate concentration to increase in the cerebral cortex of the near-term fetal sheep",
abstract = "Fetal hypoxia is an important cause of neurologic morbidity and mortality. Hypoxia-induced increase in extracellular glutamate concentration can lead to excitotoxic neuronal death in adults. The objective of this study was to test whether chronic fetal hypoxemia increases extracellular glutamate concentration in the unanesthetized intact cerebral cortex of the near-term fetal sheep. Microdialysis probes were implanted into the parasagittal parietal cortex and periventricular white matter of near-term fetal sheep. At 124 ± 1 days of gestation, extracellular glutamate concentration was determined before and during 24 h of fetal hypoxemia. Chronic hypoxemia was produced by tightening a vascular occluder placed around the maternal common iliac artery. Larger decreases in fetal arterial oxygen content were associated with larger increases in extracellular glutamate concentration in the parietal cortex (Kendall's τ = 0.81, N = 7, p = 0.005). No such relationship was detected in the periventricular white matter. Chronic hypoxemia increases extracellular glutamate concentration in the intact cerebral cortex of the unanesthetized near-term fetal sheep.",
keywords = "Cerebral cortex, Glutamate, Hypoxia, Microdialysis, Ovine fetus, Periventricular white matter",
author = "Henderson, {Janice L} and Reynolds, {James D.} and Franklin Dexter and Barry Atkins and Jim Hrdy and Dan Poduska and Penning, {Donald H.}",
year = "1998",
month = "2",
day = "10",
doi = "10.1016/S0165-3806(97)00192-2",
language = "English (US)",
volume = "105",
pages = "287--293",
journal = "Developmental Brain Research",
issn = "0165-3806",
publisher = "Elsevier BV",
number = "2",

}

TY - JOUR

T1 - Chronic hypoxemia causes extracellular glutamate concentration to increase in the cerebral cortex of the near-term fetal sheep

AU - Henderson, Janice L

AU - Reynolds, James D.

AU - Dexter, Franklin

AU - Atkins, Barry

AU - Hrdy, Jim

AU - Poduska, Dan

AU - Penning, Donald H.

PY - 1998/2/10

Y1 - 1998/2/10

N2 - Fetal hypoxia is an important cause of neurologic morbidity and mortality. Hypoxia-induced increase in extracellular glutamate concentration can lead to excitotoxic neuronal death in adults. The objective of this study was to test whether chronic fetal hypoxemia increases extracellular glutamate concentration in the unanesthetized intact cerebral cortex of the near-term fetal sheep. Microdialysis probes were implanted into the parasagittal parietal cortex and periventricular white matter of near-term fetal sheep. At 124 ± 1 days of gestation, extracellular glutamate concentration was determined before and during 24 h of fetal hypoxemia. Chronic hypoxemia was produced by tightening a vascular occluder placed around the maternal common iliac artery. Larger decreases in fetal arterial oxygen content were associated with larger increases in extracellular glutamate concentration in the parietal cortex (Kendall's τ = 0.81, N = 7, p = 0.005). No such relationship was detected in the periventricular white matter. Chronic hypoxemia increases extracellular glutamate concentration in the intact cerebral cortex of the unanesthetized near-term fetal sheep.

AB - Fetal hypoxia is an important cause of neurologic morbidity and mortality. Hypoxia-induced increase in extracellular glutamate concentration can lead to excitotoxic neuronal death in adults. The objective of this study was to test whether chronic fetal hypoxemia increases extracellular glutamate concentration in the unanesthetized intact cerebral cortex of the near-term fetal sheep. Microdialysis probes were implanted into the parasagittal parietal cortex and periventricular white matter of near-term fetal sheep. At 124 ± 1 days of gestation, extracellular glutamate concentration was determined before and during 24 h of fetal hypoxemia. Chronic hypoxemia was produced by tightening a vascular occluder placed around the maternal common iliac artery. Larger decreases in fetal arterial oxygen content were associated with larger increases in extracellular glutamate concentration in the parietal cortex (Kendall's τ = 0.81, N = 7, p = 0.005). No such relationship was detected in the periventricular white matter. Chronic hypoxemia increases extracellular glutamate concentration in the intact cerebral cortex of the unanesthetized near-term fetal sheep.

KW - Cerebral cortex

KW - Glutamate

KW - Hypoxia

KW - Microdialysis

KW - Ovine fetus

KW - Periventricular white matter

UR - http://www.scopus.com/inward/record.url?scp=0032502057&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032502057&partnerID=8YFLogxK

U2 - 10.1016/S0165-3806(97)00192-2

DO - 10.1016/S0165-3806(97)00192-2

M3 - Article

C2 - 9541746

AN - SCOPUS:0032502057

VL - 105

SP - 287

EP - 293

JO - Developmental Brain Research

JF - Developmental Brain Research

SN - 0165-3806

IS - 2

ER -