Chronic hyper-hemolysis in sickle cell anemia: Association of vascular complications and mortality with less frequent vasoocclusive pain

James G. Taylor VI, Vikki G. Nolan, Laurel Mendelsohn, Gregory J. Kato, Mark T. Gladwin, Martin H. Steinberg

Research output: Contribution to journalArticle


Background: Intravascular hemolysis in sickle cell anemia could contribute to complicate associated with nitric oxide deficiency, advancing age, and increased mortality. We have previoulsy reported that intense hemolysis is associated with validated in other populations. Methods: The distribution of serum lactic dehydrogenase (LDH) values was used as a surrogate measure of intravascular hemolysis in a contemporaneous patient group and historical adult population from the Cooperative of Sickle Cell Disease (CSSCD), all with sickle cell anemia. Chronic hyper-hemolysis was defined by the top LDH quartile and was compared to the lowest LDH quartile. Results: Hyper-hemolysis subjects had higher systolic blood pressure, higher prevalence of leg ulcers (OR 327.95% Cl 1.92-5.53, P

Original languageEnglish (US)
Article numbere2095
JournalPLoS One
Issue number5
StatePublished - May 7 2008
Externally publishedYes


ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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