Chronic hydrochlorothiazide and verapamil effects on motor activity in hypertensive baboons

Jaylan S. Turkkan, Richard P. Allen, Robert D. Hienz

Research output: Contribution to journalArticle

Abstract

Spontaneous motor activity was measured in six baboons during chronic oral dosing with a diuretic (hydrochlorothiazide/triamterene), a calcium channel blocker (verapamil), and a combination of the two drugs. Piezoelectric monitors sensitive to movement were attached to leather collars and were worn continuously by the baboons throughout the protocol. Baboons were made hypertensive during a preexperimental period by either 1) chronic administration of deoxycorticosterone acetate (DOCA)-salt or 2) surgical renal artery stenosis. Total inactive periods/day increased over baseline levels during diuretic alone and increased further during diuretic + verapamil combined. The total number of inactive periods/day returned toward baseline levels in the subsequent conditions of verapamil alone and baseline recovery. Activity levels decreased during combination dosing mainly during morning hours (0700-1100 h). Overall changes in activity occurred in the second week of dosing; this time period was found earlier to maximally decrease blood pressure and to impair behavioral performances.

Original languageEnglish (US)
Pages (from-to)567-572
Number of pages6
JournalPharmacology, Biochemistry and Behavior
Volume41
Issue number3
DOIs
StatePublished - Mar 1992

Keywords

  • Adverse side effects
  • Antihypertensive agents
  • Baboons
  • Berapamil
  • Blood pressure
  • Calcium channel blocking agents
  • DOCA-salt hypertension
  • Hydrochlorothiazide
  • Motor behavior
  • Nonhuman primates
  • Renovascular hypertension
  • Thiazide diuretics

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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