Chronic hydrochlorothiazide and verapamil effects on motor activity in hypertensive baboons

Jaylan S. Turkkan, Richard Allen, Robert D Hienz

Research output: Contribution to journalArticle

Abstract

Spontaneous motor activity was measured in six baboons during chronic oral dosing with a diuretic (hydrochlorothiazide/triamterene), a calcium channel blocker (verapamil), and a combination of the two drugs. Piezoelectric monitors sensitive to movement were attached to leather collars and were worn continuously by the baboons throughout the protocol. Baboons were made hypertensive during a preexperimental period by either 1) chronic administration of deoxycorticosterone acetate (DOCA)-salt or 2) surgical renal artery stenosis. Total inactive periods/day increased over baseline levels during diuretic alone and increased further during diuretic + verapamil combined. The total number of inactive periods/day returned toward baseline levels in the subsequent conditions of verapamil alone and baseline recovery. Activity levels decreased during combination dosing mainly during morning hours (0700-1100 h). Overall changes in activity occurred in the second week of dosing; this time period was found earlier to maximally decrease blood pressure and to impair behavioral performances.

Original languageEnglish (US)
Pages (from-to)567-572
Number of pages6
JournalPharmacology Biochemistry and Behavior
Volume41
Issue number3
DOIs
StatePublished - 1992

Fingerprint

Hydrochlorothiazide
Papio
Verapamil
Diuretics
Motor Activity
Desoxycorticosterone
Renal Artery Obstruction
Leather
Blood pressure
Calcium Channel Blockers
Drug Combinations
Acetates
Salts
Blood Pressure
Recovery
Pharmaceutical Preparations

Keywords

  • Adverse side effects
  • Antihypertensive agents
  • Baboons
  • Berapamil
  • Blood pressure
  • Calcium channel blocking agents
  • DOCA-salt hypertension
  • Hydrochlorothiazide
  • Motor behavior
  • Nonhuman primates
  • Renovascular hypertension
  • Thiazide diuretics

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Chronic hydrochlorothiazide and verapamil effects on motor activity in hypertensive baboons. / Turkkan, Jaylan S.; Allen, Richard; Hienz, Robert D.

In: Pharmacology Biochemistry and Behavior, Vol. 41, No. 3, 1992, p. 567-572.

Research output: Contribution to journalArticle

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