Chronic exposure to nicotine is associated with reduced reward-related activity in the striatum but not the midbrain

Emma Jane Rose, Thomas J. Ross, Betty Jo Salmeron, Mary Lee, Diaa M. Shakleya, Marilyn Huestis, Elliot A. Stein

Research output: Contribution to journalArticle

Abstract

The reinforcing effects of nicotine are mediated by brain regions that also support temporal difference error (TDE) processing; yet, the impact of nicotine on TDE is undetermined. Dependent smokers (n = 21) and matched control subjects (n = 21) were trained to associate a juice reward with a visual cue in a classical conditioning paradigm. Subjects subsequently underwent functional magnetic resonance imaging sessions in which they were exposed to trials where they either received juice as temporally predicted or where the juice was withheld (negative TDE) and later received unexpectedly (positive TDE). Subjects were scanned in two sessions that were identical, except that smokers had a transdermal nicotine (21 mg) or placebo patch placed before scanning. Analysis focused on regions along the trajectory of mesocorticolimbic and nigrostriatal dopaminergic pathways. There was a reduction in TDE-related function in smokers in the striatum, which did not differ as a function of patch manipulation but was predicted by the duration (years) of smoking. Activation in midbrain regions was not impacted by group or drug condition. These data suggest a differential effect of smoking status on the neural substrates of reward in distinct dopaminergic pathway regions, which may be partially attributable to chronic nicotine exposure. The failure of transdermal nicotine to alter reward-related functional processes, either within smokers or between smokers and control subjects, implies that acute nicotine patch administration is insufficient to modify reward processing, which has been linked to abstinence-induced anhedonia in smokers and may play a critical role in smoking relapse.

Original languageEnglish (US)
Pages (from-to)206-213
Number of pages8
JournalBiological Psychiatry
Volume71
Issue number3
DOIs
StatePublished - Feb 1 2012
Externally publishedYes

Fingerprint

Mesencephalon
Nicotine
Reward
Smoking
Tobacco Use Cessation Products
Anhedonia
Classical Conditioning
Cues
Placebos
Magnetic Resonance Imaging
Recurrence
Brain
Pharmaceutical Preparations

Keywords

  • fMRI
  • nicotine
  • reward
  • smoking
  • striatum
  • temporal difference error

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Rose, E. J., Ross, T. J., Salmeron, B. J., Lee, M., Shakleya, D. M., Huestis, M., & Stein, E. A. (2012). Chronic exposure to nicotine is associated with reduced reward-related activity in the striatum but not the midbrain. Biological Psychiatry, 71(3), 206-213. https://doi.org/10.1016/j.biopsych.2011.09.013

Chronic exposure to nicotine is associated with reduced reward-related activity in the striatum but not the midbrain. / Rose, Emma Jane; Ross, Thomas J.; Salmeron, Betty Jo; Lee, Mary; Shakleya, Diaa M.; Huestis, Marilyn; Stein, Elliot A.

In: Biological Psychiatry, Vol. 71, No. 3, 01.02.2012, p. 206-213.

Research output: Contribution to journalArticle

Rose, Emma Jane ; Ross, Thomas J. ; Salmeron, Betty Jo ; Lee, Mary ; Shakleya, Diaa M. ; Huestis, Marilyn ; Stein, Elliot A. / Chronic exposure to nicotine is associated with reduced reward-related activity in the striatum but not the midbrain. In: Biological Psychiatry. 2012 ; Vol. 71, No. 3. pp. 206-213.
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