Chronic exposure to biomass fuel smoke and markers of endothelial inflammation

M. A. Caravedo, P. M. Herrera, N. Mongilardi, A. de Ferrari, V. G. Davila-Roman, R. H. Gilman, R. A. Wise, C. H. Miele, J. J. Miranda, W. Checkley

Research output: Contribution to journalArticlepeer-review

Abstract

Indoor smoke exposure may affect cardiovascular disease (CVD) risk via lung-mediated inflammation, oxidative stress, and endothelial inflammation. We sought to explore the association between indoor smoke exposure from burning biomass fuels and a selected group of markers for endothelial inflammation. We compared serum concentrations of amyloid A protein, E-selectin, soluble intercellular adhesion molecule 1 (ICAM-1) and VCAM-1, von Willebrand factor (vWF), and high-sensitivity C-reactive protein (hs-CRP) in 228 biomass-exposed vs. 228 non-exposed participants living in Puno, Peru. Average age was 56 years (s.d. = 13), average BMI was 26.5 kg/m(2) (s.d. = 4.4), 48% were male, 59.4% completed high school, and 2% reported a physician diagnosis of CVD. In unadjusted analysis, serum levels of soluble ICAM-1 (330 vs. 302 ng/ml; P < 0.001), soluble VCAM-1 (403 vs. 362 ng/ml; P < 0.001), and E-selectin (54.2 vs. 52.7 ng/ml; P = 0.05) were increased in biomass-exposed vs. non-exposed participants, respectively, whereas serum levels of vWF (1148 vs. 1311 mU/ml; P < 0.001) and hs-CRP (2.56 vs. 3.12 mg/l; P < 0.001) were decreased, respectively. In adjusted analyses, chronic exposure to biomass fuels remained positively associated with serum levels of soluble ICAM-1 (P = 0.03) and VCAM-1 (P = 0.05) and E-selectin (P = 0.05), and remained negatively associated with serum levels of vWF (P = 0.02) and hs-CRP (P < 0.001). Daily exposure to biomass fuel smoke was associated with important differences in specific biomarkers of endothelial inflammation and may help explain accelerated atherosclerosis among those who are chronically exposed.

Original languageEnglish (US)
Pages (from-to)768-775
Number of pages8
JournalIndoor Air
Volume26
Issue number5
DOIs
StatePublished - Oct 1 2016

Keywords

  • Biomass fuel exposure
  • Cardiovascular disease
  • Endothelial inflammation biomarkers
  • Epidemiology
  • Household air pollution
  • Rural communities

ASJC Scopus subject areas

  • Environmental Engineering
  • Building and Construction
  • Public Health, Environmental and Occupational Health

Fingerprint

Dive into the research topics of 'Chronic exposure to biomass fuel smoke and markers of endothelial inflammation'. Together they form a unique fingerprint.

Cite this