Chronic experimental glaucoma in primates. I. Production of elevated intraocular pressure by anterior chamber injection of autologous ghost red blood cells

Harry A Quigley, E. M. Addicks

Research output: Contribution to journalArticle

Abstract

Chronic elevations of intraocular pressure (IOP) were produced in rabbit and monkey eyes by anterior chamber injection of autologous fixed red blood cells. The method confirms the possibility of secondary glaucoma due to trabecular obstruction by ghost cells in eyes with intraocular hemorrhage. In primates, decreased aqueous outflow may result from direct obstruction by free cells and macrophages as well as swelling of trabecular endothelium following phagocytosis of cellular debris. IOP elevations for from 2 days to greater than 1 mth were produced in order to study the effects of elevated IOP on ocular tissues. The model has the advantages of producing IOP elevation easily and without associated intraocular inflammation. The extensive filling of the anterior chamber necessary to produce IOP rises in healthy animal eyes leads to the disadvantage of poor visibility of the optic disk. In rabbit eyes, chronic IOP elevation leads to corneal enlargement and ectasia, making IOP measurements difficult.

Original languageEnglish (US)
Pages (from-to)126-136
Number of pages11
JournalInvestigative Ophthalmology and Visual Science
Volume19
Issue number2
StatePublished - 1980

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Anterior Chamber
Intraocular Pressure
Glaucoma
Primates
Erythrocytes
Injections
Rabbits
Pathologic Dilatations
Optic Disk
Phagocytosis
Endothelium
Haplorhini
Macrophages
Hemorrhage
Inflammation

ASJC Scopus subject areas

  • Ophthalmology

Cite this

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