Chronic disseminated epstein-barr virus infection and humoral immunodeficiency: Detection of viral antigen by elisa inhibition assay

Howard M. Lederman, Robert Yolken, Bernard J. D’Souza, Jerry A. Winkelstein

Research output: Contribution to journalArticlepeer-review

Abstract

Infectious mononucleosis is an acute viral illness caused by Epstein-Barr virus (EBV).1Although usually benign and self-limited, fatal cases of infectious mononucleosis have been described. In some instances these fatal cases have occurred sporadically. In other instances clusters of fatal cases have occurred among male members of the same kindred (the X-linked lymphoproliferative syndrome). Males with this ge-netically determined disease have variable outcomes after EBV infection. These include fatal EBV infection, B cell lymphoma, acquired immunodeficiency and aplastic pancytopenia.5The present report concerns a 2-year-old male who had acute infectious mononucleosis and subsequently developed hypogammaglobulinemia, chronic hepatitis and chronic meningoencephalitis. A novel enzyme-linked immunosorbent (ELISA) inhibition assay for EBV was used to demonstrate persistent viral antigen in the liver and central nervous system.

Original languageEnglish (US)
Pages (from-to)388-390
Number of pages3
JournalPediatric Infectious Disease
Volume2
Issue number5
StatePublished - Jan 1 1983

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)

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