Chronic demyelinating polyneuropathy in systemic lupus erythematosus

Emanuel Rechthand, David R. Cornblath, Barney J. Stern, John O. Meyerhoff

Research output: Contribution to journalArticlepeer-review

Abstract

Mononeuritis multiplex and acute demyelinating polyneuropathy (Guillain-Barré syndrome) are well known in systemic lupus erythematosus (SLE). Chronic acquired demyelinating polyneuropathy has been reported rarely in SLE. Two young women had monophasic progressive limb weakness, areflexia, elevated CSF protein, and slow nerve conduction velocities as the first manifestation of SLE. Sural nerve biopsy in one patient revealed mild loss of myelinated fibers and an increased number of thinly myelinated fibers. Steroid therapy led to improvement in both patients. These patients demonstrate that chronic demyelinating polyneuropathy can be an unusual presentation of SLE, even preceding characteristic systemic disease by months.

Original languageEnglish (US)
Pages (from-to)1375-1377
Number of pages3
JournalNeurology
Volume34
Issue number10
DOIs
StatePublished - Oct 1984

ASJC Scopus subject areas

  • Clinical Neurology

Fingerprint Dive into the research topics of 'Chronic demyelinating polyneuropathy in systemic lupus erythematosus'. Together they form a unique fingerprint.

Cite this