Chronic demyelinating polyneuropathy in systemic lupus erythematosus

Emanuel Rechthand, David Cornblath, Barney Stern, John O. Meyerhoff

Research output: Contribution to journalArticle

Abstract

Mononeuritis multiplex and acute demyelinating polyneuropathy (Guillain-Barré syndrome) are well known in systemic lupus erythematosus (SLE). Chronic acquired demyelinating polyneuropathy has been reported rarely in SLE. Two young women had monophasic progressive limb weakness, areflexia, elevated CSF protein, and slow nerve conduction velocities as the first manifestation of SLE. Sural nerve biopsy in one patient revealed mild loss of myelinated fibers and an increased number of thinly myelinated fibers. Steroid therapy led to improvement in both patients. These patients demonstrate that chronic demyelinating polyneuropathy can be an unusual presentation of SLE, even preceding characteristic systemic disease by months.

Original languageEnglish (US)
Pages (from-to)1375-1377
Number of pages3
JournalNeurology
Volume34
Issue number10
StatePublished - 1984

Fingerprint

Polyneuropathies
Systemic Lupus Erythematosus
Mononeuropathies
Sural Nerve
Neural Conduction
Extremities
Steroids
Biopsy
Proteins
Nerve
Fiber
Therapeutics

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Chronic demyelinating polyneuropathy in systemic lupus erythematosus. / Rechthand, Emanuel; Cornblath, David; Stern, Barney; Meyerhoff, John O.

In: Neurology, Vol. 34, No. 10, 1984, p. 1375-1377.

Research output: Contribution to journalArticle

Rechthand, E, Cornblath, D, Stern, B & Meyerhoff, JO 1984, 'Chronic demyelinating polyneuropathy in systemic lupus erythematosus', Neurology, vol. 34, no. 10, pp. 1375-1377.
Rechthand, Emanuel ; Cornblath, David ; Stern, Barney ; Meyerhoff, John O. / Chronic demyelinating polyneuropathy in systemic lupus erythematosus. In: Neurology. 1984 ; Vol. 34, No. 10. pp. 1375-1377.
@article{841ea2fd25b24c4384479cef83658cab,
title = "Chronic demyelinating polyneuropathy in systemic lupus erythematosus",
abstract = "Mononeuritis multiplex and acute demyelinating polyneuropathy (Guillain-Barr{\'e} syndrome) are well known in systemic lupus erythematosus (SLE). Chronic acquired demyelinating polyneuropathy has been reported rarely in SLE. Two young women had monophasic progressive limb weakness, areflexia, elevated CSF protein, and slow nerve conduction velocities as the first manifestation of SLE. Sural nerve biopsy in one patient revealed mild loss of myelinated fibers and an increased number of thinly myelinated fibers. Steroid therapy led to improvement in both patients. These patients demonstrate that chronic demyelinating polyneuropathy can be an unusual presentation of SLE, even preceding characteristic systemic disease by months.",
author = "Emanuel Rechthand and David Cornblath and Barney Stern and Meyerhoff, {John O.}",
year = "1984",
language = "English (US)",
volume = "34",
pages = "1375--1377",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "10",

}

TY - JOUR

T1 - Chronic demyelinating polyneuropathy in systemic lupus erythematosus

AU - Rechthand, Emanuel

AU - Cornblath, David

AU - Stern, Barney

AU - Meyerhoff, John O.

PY - 1984

Y1 - 1984

N2 - Mononeuritis multiplex and acute demyelinating polyneuropathy (Guillain-Barré syndrome) are well known in systemic lupus erythematosus (SLE). Chronic acquired demyelinating polyneuropathy has been reported rarely in SLE. Two young women had monophasic progressive limb weakness, areflexia, elevated CSF protein, and slow nerve conduction velocities as the first manifestation of SLE. Sural nerve biopsy in one patient revealed mild loss of myelinated fibers and an increased number of thinly myelinated fibers. Steroid therapy led to improvement in both patients. These patients demonstrate that chronic demyelinating polyneuropathy can be an unusual presentation of SLE, even preceding characteristic systemic disease by months.

AB - Mononeuritis multiplex and acute demyelinating polyneuropathy (Guillain-Barré syndrome) are well known in systemic lupus erythematosus (SLE). Chronic acquired demyelinating polyneuropathy has been reported rarely in SLE. Two young women had monophasic progressive limb weakness, areflexia, elevated CSF protein, and slow nerve conduction velocities as the first manifestation of SLE. Sural nerve biopsy in one patient revealed mild loss of myelinated fibers and an increased number of thinly myelinated fibers. Steroid therapy led to improvement in both patients. These patients demonstrate that chronic demyelinating polyneuropathy can be an unusual presentation of SLE, even preceding characteristic systemic disease by months.

UR - http://www.scopus.com/inward/record.url?scp=0021223187&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021223187&partnerID=8YFLogxK

M3 - Article

C2 - 6541313

AN - SCOPUS:0021223187

VL - 34

SP - 1375

EP - 1377

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 10

ER -