Chronic demyelinating polyneuropathy associated with eosinophilia-myalgia syndrome

M. L. Freimer, J. D. Glass, V. Chaudhry, W. R. Tyor, D. R. Cornblath, J. W. Griffin, R. W. Kuncl

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Eosinophilia-myalgia syndrome (EMS) is a newly described syndrome associated with use of L-tryptophan. A neuropathy with features of axonal degeneration has also been described in conjunction with EMS. Demyelinating polyneuropathy is not a well recognised association of the syndrome. The two patients with EMS reported presented with profound weakness and sensory loss and were found to have clinical, electrophysiological and pathological evidence of a chronic demyelinating polyneuropathy. The concurrence of this neuropathy with EMS, as well as several other features of their illness, is suggestive of an immune mediated mechanism in the pathophysiology of EMS.

Original languageEnglish (US)
Pages (from-to)352-358
Number of pages7
JournalJournal of Neurology Neurosurgery and Psychiatry
Issue number5
StatePublished - 1992

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology
  • Psychiatry and Mental health


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