TY - JOUR
T1 - Chronic cytomegalovirus infection and inflammation are associated with prevalent frailty in community-dwelling older women
AU - Schmaltz, Heidi N.
AU - Fried, Linda P.
AU - Xue, Qian Li
AU - Walston, Jeremy
AU - Leng, Sean X.
AU - Semba, Richard D.
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2005/5
Y1 - 2005/5
N2 - OBJECTIVES: To evaluate the association between asymptomatic chronic cytomegalovirus (CMV) infection and the frailty syndrome and to assess whether inflammation modifies this association. DESIGN: Cross-sectional analysis. SETTING: Women's Health and Aging Study I & II, Baltimore, Maryland. PARTICIPANTS: Seven hundred twenty-four community-dwelling women aged 70 to 79 with baseline measures of CMV, interleukin-6 (IL-6), and frailty status. MEASUREMENTS: CMV serology and IL-6 concentrations were measured using enzyme-linked immunosorbent assay. Frailty status was based on previously validated criteria: unintentional weight loss, weak grip strength, exhaustion, slow walking speed, and low level of activity. Frail women had three or more of the five components, prefrail women had one or two components, and women who were not frail had none of the components. Multinomial logistic regression adjusted for potential confounders. RESULTS: Eighty-seven percent of women were CMV seropositive, an indication of chronic infection. CMV was associated with prevalent frailty, adjusting for age, smoking history, elevated body mass index, diabetes mellitus, and congestive heart failure (CMV frail adjusted odds ratio (AOR) = 3.2, P = .03; CMV prefrail AOR = 1.5, P = .18). IL-6 interacted with CMV, significantly increasing the magnitude of this association (CMV positive and low IL-6 frail AOR = 1.5, P = .53; CMV positive and high IL-6 frail AOR = 20.3, P = .007; CMV positive and low IL-6 prefrail AOR = 0.9, P = .73; CMV positive and high IL-6 prefrail AOR = 5.5, P = .001). CONCLUSION: Chronic CMV infection is associated with prevalent frailty, a state with increased morbidity and mortality in older adults; inflammation enhances this effect. Further prospective studies are needed to establish a causal relationship between CMV, inflammation, and frailty.
AB - OBJECTIVES: To evaluate the association between asymptomatic chronic cytomegalovirus (CMV) infection and the frailty syndrome and to assess whether inflammation modifies this association. DESIGN: Cross-sectional analysis. SETTING: Women's Health and Aging Study I & II, Baltimore, Maryland. PARTICIPANTS: Seven hundred twenty-four community-dwelling women aged 70 to 79 with baseline measures of CMV, interleukin-6 (IL-6), and frailty status. MEASUREMENTS: CMV serology and IL-6 concentrations were measured using enzyme-linked immunosorbent assay. Frailty status was based on previously validated criteria: unintentional weight loss, weak grip strength, exhaustion, slow walking speed, and low level of activity. Frail women had three or more of the five components, prefrail women had one or two components, and women who were not frail had none of the components. Multinomial logistic regression adjusted for potential confounders. RESULTS: Eighty-seven percent of women were CMV seropositive, an indication of chronic infection. CMV was associated with prevalent frailty, adjusting for age, smoking history, elevated body mass index, diabetes mellitus, and congestive heart failure (CMV frail adjusted odds ratio (AOR) = 3.2, P = .03; CMV prefrail AOR = 1.5, P = .18). IL-6 interacted with CMV, significantly increasing the magnitude of this association (CMV positive and low IL-6 frail AOR = 1.5, P = .53; CMV positive and high IL-6 frail AOR = 20.3, P = .007; CMV positive and low IL-6 prefrail AOR = 0.9, P = .73; CMV positive and high IL-6 prefrail AOR = 5.5, P = .001). CONCLUSION: Chronic CMV infection is associated with prevalent frailty, a state with increased morbidity and mortality in older adults; inflammation enhances this effect. Further prospective studies are needed to establish a causal relationship between CMV, inflammation, and frailty.
KW - Aged
KW - Cytomegalovirus
KW - Frailty
KW - Inflammation
KW - Interleukin-6
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U2 - 10.1111/j.1532-5415.2005.53250.x
DO - 10.1111/j.1532-5415.2005.53250.x
M3 - Article
C2 - 15877548
AN - SCOPUS:20444481012
SN - 0002-8614
VL - 53
SP - 747
EP - 754
JO - Journal of the American Geriatrics Society
JF - Journal of the American Geriatrics Society
IS - 5
ER -