Chronic cadmium intake results in dose-related excretion of metallothionein in urine

Z. A. Shaikh, K. M. Harnett, S. A. Perlin, P. C. Huang

Research output: Contribution to journalArticlepeer-review

Abstract

Urinary excretion of metallothionein was measured by radioimmunoassay in rats given drinking water containing 5 or 50 mg cadmium/1 for up to 2 years. The metallothionein levels corresponded to the concentration of cadmium in the drinking water and increased linearly over the course of the study. These results demonstrate that urinary metallothionein is a sensitive biological indicator of oral cadmium exposure.

Original languageEnglish (US)
Pages (from-to)146-148
Number of pages3
JournalExperientia
Volume45
Issue number2
DOIs
StatePublished - Feb 1989

Keywords

  • Cadmium
  • chronic exposure
  • metallothionein
  • urinalysis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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