Chronic apraxia of speech and Broca's area

Lydia A. Trupe, Daniel D. Varma, Yessenia Gomez, David Race, Richard Leigh, Argye E. Hillis, Rebecca F. Gottesman

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Background and Purpose-Apraxia of speech (AOS) is an impairment of motor planning and programming of speech articulation and is often considered an important stroke syndrome, localizable to Broca's area. However, an influential study raised doubts on this localization and reported that AOS is attributable to lesions of the anterior insula, based on an association between chronic AOS and anterior insula lesions. We hypothesized that chronic AOS is associated with large lesions (which include the insula) or lesions to Broca's area. Method-We tested 34 participants with chronic left supratentorial stroke on an AOS battery and obtained concurrent magnetic resonance imaging. We evaluated associations between AOS and locations and volume of infarct. Results-The presence of chronic AOS (n=17) was associated with volume of infarct, but was also associated with infarct in Broca's area (and several other regions, but not anterior insula) in both volume- and age-adjusted linear regression and the dichotomous analysis. Carotid dissection was more common, and cardioembolism less common, as a cause of stroke in patients with AOS compared with those without. Severity of AOS was also strongly associated with lesion volume. Conclusions-Persistence of AOS after 12 months is associated with large left hemispheric stroke and strokes that involve Broca's area or other relatively anterior areas to which it is structurally or functionally connected. Patients with such lesions may benefit from early training in the use of technologies to support speech production and communication.

Original languageEnglish (US)
Pages (from-to)740-744
Number of pages5
Issue number3
StatePublished - Mar 2013


  • Apraxia of speech
  • Broca's area
  • Stroke syndrome

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing


Dive into the research topics of 'Chronic apraxia of speech and Broca's area'. Together they form a unique fingerprint.

Cite this