Chronic administration of sertraline, a selective serotonin uptake inhibitor, decreased the density of β-adrenergic receptors in rat frontoparietal cortex

William F. Byerley, Elizabeth J. McConnel, R. Tyler McCabe, Ted M. Dawson, Bernard I. Grosser, James K. Wamsley

Research output: Contribution to journalArticle

Abstract

Sertraline, a potent and selective inhibitor of serotonin uptake, was chronically administered to laboratory rats. Using in vitro receptor autoradiographic techniques, we found that the binding of [3H]dihydroalplrenolol ([3H]DHA) was reduced in cortex layers IV-VI. Results of a saturation experiment indicated that the reduction in cortex layer IV was due to a change in number but not affinity of β-adrenergic receptors.

Original languageEnglish (US)
Pages (from-to)377-381
Number of pages5
JournalBrain research
Volume421
Issue number1-2
DOIs
StatePublished - Sep 22 1987
Externally publishedYes

Keywords

  • In vitro receptor autoradiography
  • Serotonin
  • Sertraline
  • [H]Dihydroalprenolol
  • β-Adrenergic

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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