Sertraline, a potent and selective inhibitor of serotonin uptake, was chronically administered to laboratory rats. Using in vitro receptor autoradiographic techniques, we found that the binding of [3H]dihydroalplrenolol ([3H]DHA) was reduced in cortex layers IV-VI. Results of a saturation experiment indicated that the reduction in cortex layer IV was due to a change in number but not affinity of β-adrenergic receptors.
- In vitro receptor autoradiography
ASJC Scopus subject areas
- Developmental Biology
- Molecular Biology
- Clinical Neurology