Abstract
Chronic metabolic acidosis and osteomalacia developed in two patients following urinary diversion. Good clinical, biochemical, and histologic responses were seen following treatment with alkali alone (vitamin D was not given), despite the presence of markedly impaired glomerular filtration in one of the patients. Plasma 25-hydroxy vitamin D and 1α,25-dihydroxyvitamin D concentrations were normal before and during treatment in one of the patients and in the other were low before and normal during treatment. The results show that successful treatment of the osteomalacia of chronic acidosis is not necessarily accompanied by changes in the plasma levels of vitamin D metabolites and that even when marked glomerular dysfunction coexists with acidosis and osteomalacia, treatment with alkali may be more appropriate than the administration of vitamin D analogues.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 199-204 |
| Number of pages | 6 |
| Journal | American Journal of Medicine |
| Volume | 73 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1982 |
| Externally published | Yes |
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Chronic acidosis with metabolic bone disease. Effect of alkali on bone morphology and vitamin D metabolism. / Cunningham, John; Fraher, Lawrence J.; Clemens, Thomas; Revell, Peter A.; Papapoulos, Socrates E.
In: American Journal of Medicine, Vol. 73, No. 2, 1982, p. 199-204.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Chronic acidosis with metabolic bone disease. Effect of alkali on bone morphology and vitamin D metabolism
AU - Cunningham, John
AU - Fraher, Lawrence J.
AU - Clemens, Thomas
AU - Revell, Peter A.
AU - Papapoulos, Socrates E.
PY - 1982
Y1 - 1982
N2 - Chronic metabolic acidosis and osteomalacia developed in two patients following urinary diversion. Good clinical, biochemical, and histologic responses were seen following treatment with alkali alone (vitamin D was not given), despite the presence of markedly impaired glomerular filtration in one of the patients. Plasma 25-hydroxy vitamin D and 1α,25-dihydroxyvitamin D concentrations were normal before and during treatment in one of the patients and in the other were low before and normal during treatment. The results show that successful treatment of the osteomalacia of chronic acidosis is not necessarily accompanied by changes in the plasma levels of vitamin D metabolites and that even when marked glomerular dysfunction coexists with acidosis and osteomalacia, treatment with alkali may be more appropriate than the administration of vitamin D analogues.
AB - Chronic metabolic acidosis and osteomalacia developed in two patients following urinary diversion. Good clinical, biochemical, and histologic responses were seen following treatment with alkali alone (vitamin D was not given), despite the presence of markedly impaired glomerular filtration in one of the patients. Plasma 25-hydroxy vitamin D and 1α,25-dihydroxyvitamin D concentrations were normal before and during treatment in one of the patients and in the other were low before and normal during treatment. The results show that successful treatment of the osteomalacia of chronic acidosis is not necessarily accompanied by changes in the plasma levels of vitamin D metabolites and that even when marked glomerular dysfunction coexists with acidosis and osteomalacia, treatment with alkali may be more appropriate than the administration of vitamin D analogues.
UR - http://www.scopus.com/inward/record.url?scp=0020410077&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020410077&partnerID=8YFLogxK
U2 - 10.1016/0002-9343(82)90179-6
DO - 10.1016/0002-9343(82)90179-6
M3 - Article
C2 - 7114077
AN - SCOPUS:0020410077
VL - 73
SP - 199
EP - 204
JO - American Journal of Medicine
JF - American Journal of Medicine
SN - 0002-9343
IS - 2
ER -