Chronic acidosis with metabolic bone disease. Effect of alkali on bone morphology and vitamin D metabolism

John Cunningham, Lawrence J. Fraher, Thomas L. Clemens, Peter A. Revell, Socrates E. Papapoulos

Research output: Contribution to journalArticlepeer-review

Abstract

Chronic metabolic acidosis and osteomalacia developed in two patients following urinary diversion. Good clinical, biochemical, and histologic responses were seen following treatment with alkali alone (vitamin D was not given), despite the presence of markedly impaired glomerular filtration in one of the patients. Plasma 25-hydroxy vitamin D and 1α,25-dihydroxyvitamin D concentrations were normal before and during treatment in one of the patients and in the other were low before and normal during treatment. The results show that successful treatment of the osteomalacia of chronic acidosis is not necessarily accompanied by changes in the plasma levels of vitamin D metabolites and that even when marked glomerular dysfunction coexists with acidosis and osteomalacia, treatment with alkali may be more appropriate than the administration of vitamin D analogues.

Original languageEnglish (US)
Pages (from-to)199-204
Number of pages6
JournalThe American journal of medicine
Volume73
Issue number2
DOIs
StatePublished - Aug 1982
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Chronic acidosis with metabolic bone disease. Effect of alkali on bone morphology and vitamin D metabolism'. Together they form a unique fingerprint.

Cite this