Chronic ACE inhibitor treatment increases angiotensin type 1 receptor binding in vivo in the dog kidney

Tamas G. Zober, Maria Elena Fabucci, Wei Zheng, Phillip R. Brown, Esen Seckin, William B. Mathews, Kathryn Sandberg, Zsolt Szabo

Research output: Contribution to journalArticle

Abstract

Purpose: PET imaging has been recently introduced for investigating the type 1 angiotensin II receptor (AT1R) in vivo. The goal of the present study was to investigate the effects of acute and chronic exposure to angiotensin converting enzyme inhibitors (ACEI) on the AT1R in the dog kidney. Methods: Animals were imaged at baseline, after acute intravenous ACEI treatment and after a chronic 2-week exposure to an oral ACEI. Control animals were imaged at identical time points in the absence of ACEI treatment. Results: In vivo AT1R binding expressed by K i was increased in the renal cortex by chronic ACEI treatment (p<0.05). In vitro measurements of AT1R density (B max) also revealed significant increases in AT1R in isolated glomeruli (p<0.05). Plasma renin activity was increased, but angiotensin II (Ang II) and the Ang II/Ang I ratio showed a weak correlation with chronic ACEI treatment, consistent with an Ang II escape phenomenon. Conclusion: This study reveals, for the first time, that chronic ACEI treatment increases AT1R binding in vivo in the dog renal cortex.

Original languageEnglish (US)
Pages (from-to)1109-1116
Number of pages8
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume35
Issue number6
DOIs
StatePublished - Jun 1 2008

Keywords

  • ACE inhibitors
  • AT receptor
  • Dogs
  • In vivo imaging
  • Positron emission tomography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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