Chromosomes of condyloma acuminatum, paget�s disease, in situ carcinoma, invasive squamous cell carcinoma and malignant melanoma of the human vulva

K. Paul Katayama, J. Donald Woodruff, Howard W. Jones, Ellen Preston

Research output: Contribution to journalArticlepeer-review

Abstract

Chromosomes of 21 human vulvar lesions were studied by a direct squash method. A majority of the cells from condyloma acuminatum and Paget�s disease of the vulva were normal diploid. However, most of those from in situ and invasive neoplasia were aneuploid. All immature squamous-cell carcinomas were predominantly diploid or peridiploid and devoid of triploid elements. The mature invasive squamous-cell carcinoma with keratinization and pearl formation had scattered ploidy distribution with some triploid components. Five of six patients with mature carcinomas had lymph-node metastasis, contrary to the findings in the immature carcinomas which showed no metastasis. Cells from the melanoma of the vulva demonstrated the most striking chromosomal aberrations with a peritriploid mode and marked structural deviation of the chromosomes.

Original languageEnglish (US)
Pages (from-to)346-356
Number of pages11
JournalObstetrics and gynecology
Volume39
Issue number3
StatePublished - Mar 1972

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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