The chromosomes of atypical hyperplasia of the endometrium and carcinoma of the endometrium were studied by a direct flame-dry method without resorting to tissue culture techniques. Although the majority of the cells from an atypical hyperplasia and an adenoacanthoma of the endometrium had a normal diploid chromosome number of 46, a significant proportion of the cells showed an abnormal chromosome number of more than 46. Anaplastic adenocarcinoma of the endometrium showed both numerical and structural aberrations of chromosomes in all of the cells analyzed. An adenosquamous carcinoma of the endometrium had more than half of the cells with hyperdiploid chromosomes. A correlation between the histologic grading of malignancy and the degree of chromosme aberrations seems to exist in carcinoma of the endometrium.
ASJC Scopus subject areas
- Obstetrics and Gynecology