Chromosomes 4 and 8 implicated in a genome wide SNP linkage scan of 762 prostate cancer families collected by the ICPCG

Lingyi Lu, Geraldine Cancel-Tassin, Antoine Valeri, Olivier Cussenot, Ethan M. Lange, Kathleen A. Cooney, James M. Farnham, Nicola J. Camp, Lisa A. Cannon-Albright, Teuvo L J Tammela, Johanna Schleutker, Josef Hoegel, Kathleen Herkommer, Christiane Maier, Walther Vogel, Fredrik Wiklund, Monica Emanuelsson, Henrik Grönberg, Kathleen E. Wiley, Sarah D. Isaacs & 38 others Patrick Walsh, Brian T. Helfand, Donghui Kan, William J. Catalona, Janet L. Stanford, Liesel M. Fitzgerald, Bo Johanneson, Kerry Deutsch, Laura McIntosh, Elaine A. Ostrander, Stephen N. Thibodeau, Shannon K. McDonnell, Scott Hebbring, Daniel J. Schaid, Alice S. Whittemore, Ingrid Oakley-Girvan, Chih Lin Hsieh, Isaac Powell, Joan E. Bailey-Wilson, Cheryl D. Cropp, Claire Simpson, John D. Carpten, Daniela Seminara, S. Lilly Zheng, Jianfen Xu, Graham G. Giles, Gianluca Severi, John L. Hopper, Dallas R. English, William D. Foulkes, Lovise Maehle, Pal Moller, Michael D. Badzioch, Steve Edwards, Michelle Guy, Ros Eeles, Douglas Easton, William B Isaacs

Research output: Contribution to journalArticle

Abstract

BACKGROUND In spite of intensive efforts, understanding of the genetic aspects of familial prostate cancer (PC) remains largely incomplete. In a previous microsatellite-based linkage scan of 1,233 PC families, we identified suggestive evidence for linkage (i.e., LOD ≥ 1.86) at 5q12, 15q11, 17q21, 22q12, and two loci on 8p, with additional regions implicated in subsets of families defined by age at diagnosis, disease aggressiveness, or number of affected members. METHODS In an attempt to replicate these findings and increase linkage resolution, we used the Illumina 6000 SNP linkage panel to perform a genome-wide linkage scan of an independent set of 762 multiplex PC families, collected by 11 International Consortium for Prostate Cancer Genetics (ICPCG) groups. RESULTS Of the regions identified previously, modest evidence of replication was observed only on the short arm of chromosome 8, where HLOD scores of 1.63 and 3.60 were observed in the complete set of families and families with young average age at diagnosis, respectively. The most significant linkage signals found in the complete set of families were observed across a broad, 37 cM interval on 4q13-25, with LOD scores ranging from 2.02 to 2.62, increasing to 4.50 in families with older average age at diagnosis. In families with multiple cases presenting with more aggressive disease, LOD scores over 3.0 were observed at 8q24 in the vicinity of previously identified common PC risk variants, as well as MYC, an important gene in PC biology. CONCLUSIONS These results will be useful in prioritizing future susceptibility gene discovery efforts in this common cancer.

Original languageEnglish (US)
Pages (from-to)410-426
Number of pages17
JournalProstate
Volume72
Issue number4
DOIs
StatePublished - Mar 2012

Fingerprint

Chromosomes, Human, Pair 8
Chromosomes, Human, Pair 4
Single Nucleotide Polymorphism
Prostatic Neoplasms
Genome
Genetic Association Studies
Microsatellite Repeats
Genes
Neoplasms

Keywords

  • 8q24
  • hereditary
  • prostate cancer
  • susceptibility

ASJC Scopus subject areas

  • Urology
  • Oncology

Cite this

Chromosomes 4 and 8 implicated in a genome wide SNP linkage scan of 762 prostate cancer families collected by the ICPCG. / Lu, Lingyi; Cancel-Tassin, Geraldine; Valeri, Antoine; Cussenot, Olivier; Lange, Ethan M.; Cooney, Kathleen A.; Farnham, James M.; Camp, Nicola J.; Cannon-Albright, Lisa A.; Tammela, Teuvo L J; Schleutker, Johanna; Hoegel, Josef; Herkommer, Kathleen; Maier, Christiane; Vogel, Walther; Wiklund, Fredrik; Emanuelsson, Monica; Grönberg, Henrik; Wiley, Kathleen E.; Isaacs, Sarah D.; Walsh, Patrick; Helfand, Brian T.; Kan, Donghui; Catalona, William J.; Stanford, Janet L.; Fitzgerald, Liesel M.; Johanneson, Bo; Deutsch, Kerry; McIntosh, Laura; Ostrander, Elaine A.; Thibodeau, Stephen N.; McDonnell, Shannon K.; Hebbring, Scott; Schaid, Daniel J.; Whittemore, Alice S.; Oakley-Girvan, Ingrid; Hsieh, Chih Lin; Powell, Isaac; Bailey-Wilson, Joan E.; Cropp, Cheryl D.; Simpson, Claire; Carpten, John D.; Seminara, Daniela; Zheng, S. Lilly; Xu, Jianfen; Giles, Graham G.; Severi, Gianluca; Hopper, John L.; English, Dallas R.; Foulkes, William D.; Maehle, Lovise; Moller, Pal; Badzioch, Michael D.; Edwards, Steve; Guy, Michelle; Eeles, Ros; Easton, Douglas; Isaacs, William B.

In: Prostate, Vol. 72, No. 4, 03.2012, p. 410-426.

Research output: Contribution to journalArticle

Lu, L, Cancel-Tassin, G, Valeri, A, Cussenot, O, Lange, EM, Cooney, KA, Farnham, JM, Camp, NJ, Cannon-Albright, LA, Tammela, TLJ, Schleutker, J, Hoegel, J, Herkommer, K, Maier, C, Vogel, W, Wiklund, F, Emanuelsson, M, Grönberg, H, Wiley, KE, Isaacs, SD, Walsh, P, Helfand, BT, Kan, D, Catalona, WJ, Stanford, JL, Fitzgerald, LM, Johanneson, B, Deutsch, K, McIntosh, L, Ostrander, EA, Thibodeau, SN, McDonnell, SK, Hebbring, S, Schaid, DJ, Whittemore, AS, Oakley-Girvan, I, Hsieh, CL, Powell, I, Bailey-Wilson, JE, Cropp, CD, Simpson, C, Carpten, JD, Seminara, D, Zheng, SL, Xu, J, Giles, GG, Severi, G, Hopper, JL, English, DR, Foulkes, WD, Maehle, L, Moller, P, Badzioch, MD, Edwards, S, Guy, M, Eeles, R, Easton, D & Isaacs, WB 2012, 'Chromosomes 4 and 8 implicated in a genome wide SNP linkage scan of 762 prostate cancer families collected by the ICPCG', Prostate, vol. 72, no. 4, pp. 410-426. https://doi.org/10.1002/pros.21443
Lu, Lingyi ; Cancel-Tassin, Geraldine ; Valeri, Antoine ; Cussenot, Olivier ; Lange, Ethan M. ; Cooney, Kathleen A. ; Farnham, James M. ; Camp, Nicola J. ; Cannon-Albright, Lisa A. ; Tammela, Teuvo L J ; Schleutker, Johanna ; Hoegel, Josef ; Herkommer, Kathleen ; Maier, Christiane ; Vogel, Walther ; Wiklund, Fredrik ; Emanuelsson, Monica ; Grönberg, Henrik ; Wiley, Kathleen E. ; Isaacs, Sarah D. ; Walsh, Patrick ; Helfand, Brian T. ; Kan, Donghui ; Catalona, William J. ; Stanford, Janet L. ; Fitzgerald, Liesel M. ; Johanneson, Bo ; Deutsch, Kerry ; McIntosh, Laura ; Ostrander, Elaine A. ; Thibodeau, Stephen N. ; McDonnell, Shannon K. ; Hebbring, Scott ; Schaid, Daniel J. ; Whittemore, Alice S. ; Oakley-Girvan, Ingrid ; Hsieh, Chih Lin ; Powell, Isaac ; Bailey-Wilson, Joan E. ; Cropp, Cheryl D. ; Simpson, Claire ; Carpten, John D. ; Seminara, Daniela ; Zheng, S. Lilly ; Xu, Jianfen ; Giles, Graham G. ; Severi, Gianluca ; Hopper, John L. ; English, Dallas R. ; Foulkes, William D. ; Maehle, Lovise ; Moller, Pal ; Badzioch, Michael D. ; Edwards, Steve ; Guy, Michelle ; Eeles, Ros ; Easton, Douglas ; Isaacs, William B. / Chromosomes 4 and 8 implicated in a genome wide SNP linkage scan of 762 prostate cancer families collected by the ICPCG. In: Prostate. 2012 ; Vol. 72, No. 4. pp. 410-426.
@article{db027687138444049825913a6bc2b048,
title = "Chromosomes 4 and 8 implicated in a genome wide SNP linkage scan of 762 prostate cancer families collected by the ICPCG",
abstract = "BACKGROUND In spite of intensive efforts, understanding of the genetic aspects of familial prostate cancer (PC) remains largely incomplete. In a previous microsatellite-based linkage scan of 1,233 PC families, we identified suggestive evidence for linkage (i.e., LOD ≥ 1.86) at 5q12, 15q11, 17q21, 22q12, and two loci on 8p, with additional regions implicated in subsets of families defined by age at diagnosis, disease aggressiveness, or number of affected members. METHODS In an attempt to replicate these findings and increase linkage resolution, we used the Illumina 6000 SNP linkage panel to perform a genome-wide linkage scan of an independent set of 762 multiplex PC families, collected by 11 International Consortium for Prostate Cancer Genetics (ICPCG) groups. RESULTS Of the regions identified previously, modest evidence of replication was observed only on the short arm of chromosome 8, where HLOD scores of 1.63 and 3.60 were observed in the complete set of families and families with young average age at diagnosis, respectively. The most significant linkage signals found in the complete set of families were observed across a broad, 37 cM interval on 4q13-25, with LOD scores ranging from 2.02 to 2.62, increasing to 4.50 in families with older average age at diagnosis. In families with multiple cases presenting with more aggressive disease, LOD scores over 3.0 were observed at 8q24 in the vicinity of previously identified common PC risk variants, as well as MYC, an important gene in PC biology. CONCLUSIONS These results will be useful in prioritizing future susceptibility gene discovery efforts in this common cancer.",
keywords = "8q24, hereditary, prostate cancer, susceptibility",
author = "Lingyi Lu and Geraldine Cancel-Tassin and Antoine Valeri and Olivier Cussenot and Lange, {Ethan M.} and Cooney, {Kathleen A.} and Farnham, {James M.} and Camp, {Nicola J.} and Cannon-Albright, {Lisa A.} and Tammela, {Teuvo L J} and Johanna Schleutker and Josef Hoegel and Kathleen Herkommer and Christiane Maier and Walther Vogel and Fredrik Wiklund and Monica Emanuelsson and Henrik Gr{\"o}nberg and Wiley, {Kathleen E.} and Isaacs, {Sarah D.} and Patrick Walsh and Helfand, {Brian T.} and Donghui Kan and Catalona, {William J.} and Stanford, {Janet L.} and Fitzgerald, {Liesel M.} and Bo Johanneson and Kerry Deutsch and Laura McIntosh and Ostrander, {Elaine A.} and Thibodeau, {Stephen N.} and McDonnell, {Shannon K.} and Scott Hebbring and Schaid, {Daniel J.} and Whittemore, {Alice S.} and Ingrid Oakley-Girvan and Hsieh, {Chih Lin} and Isaac Powell and Bailey-Wilson, {Joan E.} and Cropp, {Cheryl D.} and Claire Simpson and Carpten, {John D.} and Daniela Seminara and Zheng, {S. Lilly} and Jianfen Xu and Giles, {Graham G.} and Gianluca Severi and Hopper, {John L.} and English, {Dallas R.} and Foulkes, {William D.} and Lovise Maehle and Pal Moller and Badzioch, {Michael D.} and Steve Edwards and Michelle Guy and Ros Eeles and Douglas Easton and Isaacs, {William B}",
year = "2012",
month = "3",
doi = "10.1002/pros.21443",
language = "English (US)",
volume = "72",
pages = "410--426",
journal = "Prostate",
issn = "0270-4137",
publisher = "Wiley-Liss Inc.",
number = "4",

}

TY - JOUR

T1 - Chromosomes 4 and 8 implicated in a genome wide SNP linkage scan of 762 prostate cancer families collected by the ICPCG

AU - Lu, Lingyi

AU - Cancel-Tassin, Geraldine

AU - Valeri, Antoine

AU - Cussenot, Olivier

AU - Lange, Ethan M.

AU - Cooney, Kathleen A.

AU - Farnham, James M.

AU - Camp, Nicola J.

AU - Cannon-Albright, Lisa A.

AU - Tammela, Teuvo L J

AU - Schleutker, Johanna

AU - Hoegel, Josef

AU - Herkommer, Kathleen

AU - Maier, Christiane

AU - Vogel, Walther

AU - Wiklund, Fredrik

AU - Emanuelsson, Monica

AU - Grönberg, Henrik

AU - Wiley, Kathleen E.

AU - Isaacs, Sarah D.

AU - Walsh, Patrick

AU - Helfand, Brian T.

AU - Kan, Donghui

AU - Catalona, William J.

AU - Stanford, Janet L.

AU - Fitzgerald, Liesel M.

AU - Johanneson, Bo

AU - Deutsch, Kerry

AU - McIntosh, Laura

AU - Ostrander, Elaine A.

AU - Thibodeau, Stephen N.

AU - McDonnell, Shannon K.

AU - Hebbring, Scott

AU - Schaid, Daniel J.

AU - Whittemore, Alice S.

AU - Oakley-Girvan, Ingrid

AU - Hsieh, Chih Lin

AU - Powell, Isaac

AU - Bailey-Wilson, Joan E.

AU - Cropp, Cheryl D.

AU - Simpson, Claire

AU - Carpten, John D.

AU - Seminara, Daniela

AU - Zheng, S. Lilly

AU - Xu, Jianfen

AU - Giles, Graham G.

AU - Severi, Gianluca

AU - Hopper, John L.

AU - English, Dallas R.

AU - Foulkes, William D.

AU - Maehle, Lovise

AU - Moller, Pal

AU - Badzioch, Michael D.

AU - Edwards, Steve

AU - Guy, Michelle

AU - Eeles, Ros

AU - Easton, Douglas

AU - Isaacs, William B

PY - 2012/3

Y1 - 2012/3

N2 - BACKGROUND In spite of intensive efforts, understanding of the genetic aspects of familial prostate cancer (PC) remains largely incomplete. In a previous microsatellite-based linkage scan of 1,233 PC families, we identified suggestive evidence for linkage (i.e., LOD ≥ 1.86) at 5q12, 15q11, 17q21, 22q12, and two loci on 8p, with additional regions implicated in subsets of families defined by age at diagnosis, disease aggressiveness, or number of affected members. METHODS In an attempt to replicate these findings and increase linkage resolution, we used the Illumina 6000 SNP linkage panel to perform a genome-wide linkage scan of an independent set of 762 multiplex PC families, collected by 11 International Consortium for Prostate Cancer Genetics (ICPCG) groups. RESULTS Of the regions identified previously, modest evidence of replication was observed only on the short arm of chromosome 8, where HLOD scores of 1.63 and 3.60 were observed in the complete set of families and families with young average age at diagnosis, respectively. The most significant linkage signals found in the complete set of families were observed across a broad, 37 cM interval on 4q13-25, with LOD scores ranging from 2.02 to 2.62, increasing to 4.50 in families with older average age at diagnosis. In families with multiple cases presenting with more aggressive disease, LOD scores over 3.0 were observed at 8q24 in the vicinity of previously identified common PC risk variants, as well as MYC, an important gene in PC biology. CONCLUSIONS These results will be useful in prioritizing future susceptibility gene discovery efforts in this common cancer.

AB - BACKGROUND In spite of intensive efforts, understanding of the genetic aspects of familial prostate cancer (PC) remains largely incomplete. In a previous microsatellite-based linkage scan of 1,233 PC families, we identified suggestive evidence for linkage (i.e., LOD ≥ 1.86) at 5q12, 15q11, 17q21, 22q12, and two loci on 8p, with additional regions implicated in subsets of families defined by age at diagnosis, disease aggressiveness, or number of affected members. METHODS In an attempt to replicate these findings and increase linkage resolution, we used the Illumina 6000 SNP linkage panel to perform a genome-wide linkage scan of an independent set of 762 multiplex PC families, collected by 11 International Consortium for Prostate Cancer Genetics (ICPCG) groups. RESULTS Of the regions identified previously, modest evidence of replication was observed only on the short arm of chromosome 8, where HLOD scores of 1.63 and 3.60 were observed in the complete set of families and families with young average age at diagnosis, respectively. The most significant linkage signals found in the complete set of families were observed across a broad, 37 cM interval on 4q13-25, with LOD scores ranging from 2.02 to 2.62, increasing to 4.50 in families with older average age at diagnosis. In families with multiple cases presenting with more aggressive disease, LOD scores over 3.0 were observed at 8q24 in the vicinity of previously identified common PC risk variants, as well as MYC, an important gene in PC biology. CONCLUSIONS These results will be useful in prioritizing future susceptibility gene discovery efforts in this common cancer.

KW - 8q24

KW - hereditary

KW - prostate cancer

KW - susceptibility

UR - http://www.scopus.com/inward/record.url?scp=84856037428&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84856037428&partnerID=8YFLogxK

U2 - 10.1002/pros.21443

DO - 10.1002/pros.21443

M3 - Article

VL - 72

SP - 410

EP - 426

JO - Prostate

JF - Prostate

SN - 0270-4137

IS - 4

ER -