Chromosome segregation and cancer: Cutting through the mystery

Prasad V. Jallepalli, Christoph Lengauer

Research output: Contribution to journalArticle

Abstract

Mitosis is the most dramatic - and potentially dangerous - event in the cell cycle, as sister chromatids are irreversibly segregated to daughter cells. Defects in the checkpoints that normally maintain the fidelity of this process can lead to chromosomal instability (CIN) and cancer. However, CIN - a driving force of tumorigenesis - could be the cancer cell's ultimate vulnerability. An important goal is to identify novel anticancer compounds that directly target the mitotic errors at the heart of CIN.

Original languageEnglish (US)
Pages (from-to)109-117
Number of pages9
JournalNature Reviews Cancer
Volume1
Issue number2
StatePublished - 2001

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Chromosomal Instability
Chromosome Segregation
Neoplasms
Chromatids
Mitosis
Cell Cycle
Carcinogenesis

ASJC Scopus subject areas

  • Cancer Research

Cite this

Jallepalli, P. V., & Lengauer, C. (2001). Chromosome segregation and cancer: Cutting through the mystery. Nature Reviews Cancer, 1(2), 109-117.

Chromosome segregation and cancer : Cutting through the mystery. / Jallepalli, Prasad V.; Lengauer, Christoph.

In: Nature Reviews Cancer, Vol. 1, No. 2, 2001, p. 109-117.

Research output: Contribution to journalArticle

Jallepalli, PV & Lengauer, C 2001, 'Chromosome segregation and cancer: Cutting through the mystery', Nature Reviews Cancer, vol. 1, no. 2, pp. 109-117.
Jallepalli, Prasad V. ; Lengauer, Christoph. / Chromosome segregation and cancer : Cutting through the mystery. In: Nature Reviews Cancer. 2001 ; Vol. 1, No. 2. pp. 109-117.
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