Chromosome missegregation rate predicts whether aneuploidy will promote or suppress tumors

Alain D. Silk, Lauren M. Zasadil, Andrew J. Holland, Benjamin Vitre, Don W. Cleveland, Beth A. Weaver

Research output: Contribution to journalArticlepeer-review


Aneuploidy, a chromosome content other than a multiple of the haploid number, is a common feature of cancer cells. Whole chromosomal aneuploidy accompanying ongoing chromosomal instability in mice resulting fromreduced levels of the centromere-linkedmotor protein CENP-E has been reported to increase the incidence of spleen and lung tumors, but to suppress tumors in three other contexts. Exacerbating chromosome missegregation in CENP-E+ mice by reducing levels of another mitotic checkpoint component, Mad2, is now shown to result in elevated cell death and decreased tumor formation compared with reduction of either protein alone. Furthermore, we determine that the additional contexts in which increased whole-chromosome missegregation resulting from reduced CENP-E suppresses tumor formation have a preexisting, elevated basal level of chromosome missegregation that is exacerbated by reduction of CENP-E. Tumors arising from primary causes that do not generate chromosomal instability, including loss of the INK4a tumor suppressor and microsatellite instability from reduction of the DNA mismatch repair protein MLH1, are unaffected by CENP-E-dependent chromosome missegregation. These findings support a model in which low rates of chromosome missegregation can promote tumorigenesis, whereas missegregation of high numbers of chromosomes leads to cell death and tumor suppression.

Original languageEnglish (US)
Pages (from-to)E4134-E4141
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number44
StatePublished - Oct 29 2013

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Chromosome missegregation rate predicts whether aneuploidy will promote or suppress tumors'. Together they form a unique fingerprint.

Cite this