Chromosome-centric human proteome project (C-HPP): Chromosome 12

Sakdithep Chaiyarit, Nilubon Singhto, Yi Ju Chen, Chia Ying Cheng, Wararat Chiangjong, Rattiyaporn Kanlaya, Henry H N Lam, Paleerath Peerapen, Ting Yi Sung, Phornpimon Tipthara, Akhilesh Pandey, Terence C W Poon, Yu Ju Chen, Ravi Sirdeshmukh, Maxey C M Chung, Visith Thongboonkerd

Research output: Contribution to journalArticle

Abstract

Following an official announcement of the Chromosome-centric Human Proteome Project (C-HPP), the Chromosome 12 (Ch12) Consortium has been established by five representative teams from five Asian countries including Thailand (Siriraj Hospital, Mahidol University), Singapore (National University of Singapore), Taiwan (Academia Sinica), Hong Kong (The Chinese University of Hong Kong), and India (Institute of Bioinformatics). We have worked closely together to extensively and systematically analyze all missing and known proteins encoded by Ch12 for their tissue/cellular/subcellular localizations. The target organs/tissues/cells include kidney, brain, gastrointestinal tissues, blood/immune cells, and stem cells. In the later phase, post-translational modifications and functional significance of Ch12-encoded proteins as well as their associations with human diseases (i.e., immune diseases, metabolic disorders, and cancers) will be defined. We have collaborated with other chromosome teams, Human Kidney and Urine Proteome Project (HKUPP), AOHUPO Membrane Proteomics Initiative, and other existing HUPO initiatives in the Biology/Disease-Based Human Proteome Project (B/D-HPP) to delineate functional roles and medical implications of Ch12-encoded proteins. The data set to be obtained from this multicountry consortium will be an important piece of the jigsaw puzzle to fulfill the missions and goals of the C-HPP and the global Human Proteome Project (HPP).

Original languageEnglish (US)
Pages (from-to)3160-3165
Number of pages6
JournalJournal of Proteome Research
Volume13
Issue number7
DOIs
StatePublished - Jul 3 2014

Fingerprint

Chromosomes, Human, Pair 12
Human Chromosomes
Proteome
Chromosomes
Singapore
Hong Kong
Tissue
Kidney
Proteins
Immune System Diseases
Thailand
Post Translational Protein Processing
Computational Biology
Taiwan
Proteomics
India
Blood Cells
Stem Cells
Bioinformatics
Stem cells

Keywords

  • B/D-HPP
  • C-HPP
  • chromosome 12
  • chromosome-centric
  • HPP
  • Human Proteome Organization
  • Human Proteome Project
  • HUPO

ASJC Scopus subject areas

  • Biochemistry
  • Chemistry(all)
  • Medicine(all)

Cite this

Chaiyarit, S., Singhto, N., Chen, Y. J., Cheng, C. Y., Chiangjong, W., Kanlaya, R., ... Thongboonkerd, V. (2014). Chromosome-centric human proteome project (C-HPP): Chromosome 12. Journal of Proteome Research, 13(7), 3160-3165. https://doi.org/10.1021/pr500009j

Chromosome-centric human proteome project (C-HPP) : Chromosome 12. / Chaiyarit, Sakdithep; Singhto, Nilubon; Chen, Yi Ju; Cheng, Chia Ying; Chiangjong, Wararat; Kanlaya, Rattiyaporn; Lam, Henry H N; Peerapen, Paleerath; Sung, Ting Yi; Tipthara, Phornpimon; Pandey, Akhilesh; Poon, Terence C W; Chen, Yu Ju; Sirdeshmukh, Ravi; Chung, Maxey C M; Thongboonkerd, Visith.

In: Journal of Proteome Research, Vol. 13, No. 7, 03.07.2014, p. 3160-3165.

Research output: Contribution to journalArticle

Chaiyarit, S, Singhto, N, Chen, YJ, Cheng, CY, Chiangjong, W, Kanlaya, R, Lam, HHN, Peerapen, P, Sung, TY, Tipthara, P, Pandey, A, Poon, TCW, Chen, YJ, Sirdeshmukh, R, Chung, MCM & Thongboonkerd, V 2014, 'Chromosome-centric human proteome project (C-HPP): Chromosome 12', Journal of Proteome Research, vol. 13, no. 7, pp. 3160-3165. https://doi.org/10.1021/pr500009j
Chaiyarit S, Singhto N, Chen YJ, Cheng CY, Chiangjong W, Kanlaya R et al. Chromosome-centric human proteome project (C-HPP): Chromosome 12. Journal of Proteome Research. 2014 Jul 3;13(7):3160-3165. https://doi.org/10.1021/pr500009j
Chaiyarit, Sakdithep ; Singhto, Nilubon ; Chen, Yi Ju ; Cheng, Chia Ying ; Chiangjong, Wararat ; Kanlaya, Rattiyaporn ; Lam, Henry H N ; Peerapen, Paleerath ; Sung, Ting Yi ; Tipthara, Phornpimon ; Pandey, Akhilesh ; Poon, Terence C W ; Chen, Yu Ju ; Sirdeshmukh, Ravi ; Chung, Maxey C M ; Thongboonkerd, Visith. / Chromosome-centric human proteome project (C-HPP) : Chromosome 12. In: Journal of Proteome Research. 2014 ; Vol. 13, No. 7. pp. 3160-3165.
@article{4af33cd2153e43169b1005bd7009617c,
title = "Chromosome-centric human proteome project (C-HPP): Chromosome 12",
abstract = "Following an official announcement of the Chromosome-centric Human Proteome Project (C-HPP), the Chromosome 12 (Ch12) Consortium has been established by five representative teams from five Asian countries including Thailand (Siriraj Hospital, Mahidol University), Singapore (National University of Singapore), Taiwan (Academia Sinica), Hong Kong (The Chinese University of Hong Kong), and India (Institute of Bioinformatics). We have worked closely together to extensively and systematically analyze all missing and known proteins encoded by Ch12 for their tissue/cellular/subcellular localizations. The target organs/tissues/cells include kidney, brain, gastrointestinal tissues, blood/immune cells, and stem cells. In the later phase, post-translational modifications and functional significance of Ch12-encoded proteins as well as their associations with human diseases (i.e., immune diseases, metabolic disorders, and cancers) will be defined. We have collaborated with other chromosome teams, Human Kidney and Urine Proteome Project (HKUPP), AOHUPO Membrane Proteomics Initiative, and other existing HUPO initiatives in the Biology/Disease-Based Human Proteome Project (B/D-HPP) to delineate functional roles and medical implications of Ch12-encoded proteins. The data set to be obtained from this multicountry consortium will be an important piece of the jigsaw puzzle to fulfill the missions and goals of the C-HPP and the global Human Proteome Project (HPP).",
keywords = "B/D-HPP, C-HPP, chromosome 12, chromosome-centric, HPP, Human Proteome Organization, Human Proteome Project, HUPO",
author = "Sakdithep Chaiyarit and Nilubon Singhto and Chen, {Yi Ju} and Cheng, {Chia Ying} and Wararat Chiangjong and Rattiyaporn Kanlaya and Lam, {Henry H N} and Paleerath Peerapen and Sung, {Ting Yi} and Phornpimon Tipthara and Akhilesh Pandey and Poon, {Terence C W} and Chen, {Yu Ju} and Ravi Sirdeshmukh and Chung, {Maxey C M} and Visith Thongboonkerd",
year = "2014",
month = "7",
day = "3",
doi = "10.1021/pr500009j",
language = "English (US)",
volume = "13",
pages = "3160--3165",
journal = "Journal of Proteome Research",
issn = "1535-3893",
publisher = "American Chemical Society",
number = "7",

}

TY - JOUR

T1 - Chromosome-centric human proteome project (C-HPP)

T2 - Chromosome 12

AU - Chaiyarit, Sakdithep

AU - Singhto, Nilubon

AU - Chen, Yi Ju

AU - Cheng, Chia Ying

AU - Chiangjong, Wararat

AU - Kanlaya, Rattiyaporn

AU - Lam, Henry H N

AU - Peerapen, Paleerath

AU - Sung, Ting Yi

AU - Tipthara, Phornpimon

AU - Pandey, Akhilesh

AU - Poon, Terence C W

AU - Chen, Yu Ju

AU - Sirdeshmukh, Ravi

AU - Chung, Maxey C M

AU - Thongboonkerd, Visith

PY - 2014/7/3

Y1 - 2014/7/3

N2 - Following an official announcement of the Chromosome-centric Human Proteome Project (C-HPP), the Chromosome 12 (Ch12) Consortium has been established by five representative teams from five Asian countries including Thailand (Siriraj Hospital, Mahidol University), Singapore (National University of Singapore), Taiwan (Academia Sinica), Hong Kong (The Chinese University of Hong Kong), and India (Institute of Bioinformatics). We have worked closely together to extensively and systematically analyze all missing and known proteins encoded by Ch12 for their tissue/cellular/subcellular localizations. The target organs/tissues/cells include kidney, brain, gastrointestinal tissues, blood/immune cells, and stem cells. In the later phase, post-translational modifications and functional significance of Ch12-encoded proteins as well as their associations with human diseases (i.e., immune diseases, metabolic disorders, and cancers) will be defined. We have collaborated with other chromosome teams, Human Kidney and Urine Proteome Project (HKUPP), AOHUPO Membrane Proteomics Initiative, and other existing HUPO initiatives in the Biology/Disease-Based Human Proteome Project (B/D-HPP) to delineate functional roles and medical implications of Ch12-encoded proteins. The data set to be obtained from this multicountry consortium will be an important piece of the jigsaw puzzle to fulfill the missions and goals of the C-HPP and the global Human Proteome Project (HPP).

AB - Following an official announcement of the Chromosome-centric Human Proteome Project (C-HPP), the Chromosome 12 (Ch12) Consortium has been established by five representative teams from five Asian countries including Thailand (Siriraj Hospital, Mahidol University), Singapore (National University of Singapore), Taiwan (Academia Sinica), Hong Kong (The Chinese University of Hong Kong), and India (Institute of Bioinformatics). We have worked closely together to extensively and systematically analyze all missing and known proteins encoded by Ch12 for their tissue/cellular/subcellular localizations. The target organs/tissues/cells include kidney, brain, gastrointestinal tissues, blood/immune cells, and stem cells. In the later phase, post-translational modifications and functional significance of Ch12-encoded proteins as well as their associations with human diseases (i.e., immune diseases, metabolic disorders, and cancers) will be defined. We have collaborated with other chromosome teams, Human Kidney and Urine Proteome Project (HKUPP), AOHUPO Membrane Proteomics Initiative, and other existing HUPO initiatives in the Biology/Disease-Based Human Proteome Project (B/D-HPP) to delineate functional roles and medical implications of Ch12-encoded proteins. The data set to be obtained from this multicountry consortium will be an important piece of the jigsaw puzzle to fulfill the missions and goals of the C-HPP and the global Human Proteome Project (HPP).

KW - B/D-HPP

KW - C-HPP

KW - chromosome 12

KW - chromosome-centric

KW - HPP

KW - Human Proteome Organization

KW - Human Proteome Project

KW - HUPO

UR - http://www.scopus.com/inward/record.url?scp=84903750474&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84903750474&partnerID=8YFLogxK

U2 - 10.1021/pr500009j

DO - 10.1021/pr500009j

M3 - Article

C2 - 24831074

AN - SCOPUS:84903750474

VL - 13

SP - 3160

EP - 3165

JO - Journal of Proteome Research

JF - Journal of Proteome Research

SN - 1535-3893

IS - 7

ER -