Chromosome abnormalities in ovarian adenocarcinoma: II. Prognostic impact of nonrandom chromosome abnormalities in 244 cases

Raymond Taetle, Mikel Aickin, Lita Panda, Julia Emerson, Roe Denise, Floyd Thompson, John Davis, Jeffrey Trent, David Alberts

Research output: Contribution to journalArticle

Abstract

In a large series of ovarian carcinomas from 244 patients, 134 cases had chromosome rearrangements. We showed before that the pattern of chromosome breakpoints involved 21 separate chromosome regions nonrandomly and, in 90% of cases with breaks, the breakpoints occurred within 13 commonly involved regions. Log-rank and proportional hazards regression analyses showed that the aggregate presence of a chromosome breakpoint in any of 21 nonrandomly involved regions and breaks in 9 distinct regions (1p1, 1q2, 1p3, 3p1, 6p2, 11p1, 11q1, 12q2, and 13p1) were associated with reduced patient survival. Breakpoints in other areas of the genome, including other nonrandomly involved regions, were not associated with decreased survival. Because many cases had breakpoints in more than one nonrandomly involved region, proportional hazards regression was also used to analyze for effects of each nonrandomly involved region, controlling for effects of other regions. With this approach, only breakpoints within Ip1 and 3p1 retained independent, deleterious effects on survival. Similarly, when nonrandomly involved regions were entered into a proportional hazards model containing clinical variables associated with altered patient survival (tumor grade, tumor stage, and residual disease > 1 cm after resection), only 1 p1 (P = 0.007) and 3p1 (P = 0.04) were associated with independent, negative effects on survival. These studies demonstrate that chromosome breakpoints within specific, nonrandomly involved chromosome regions are associated with impaired survival in ovarian cancers. Regions 1p1 and 3p1 are identified as areas of particular significance and are appropriate targets for analytical techniques such as SAGE and microarray analysis.

Original languageEnglish (US)
Pages (from-to)46-52
Number of pages7
JournalGenes Chromosomes and Cancer
Volume25
Issue number1
DOIs
StatePublished - May 1999
Externally publishedYes

Fingerprint

Chromosome Aberrations
Adenocarcinoma
Chromosome Breakpoints
Survival
Chromosomes
Chromosomes, Human, Pair 21
Residual Neoplasm
Microarray Analysis
Proportional Hazards Models
Ovarian Neoplasms
Regression Analysis
Genome
Carcinoma
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Genetics

Cite this

Chromosome abnormalities in ovarian adenocarcinoma : II. Prognostic impact of nonrandom chromosome abnormalities in 244 cases. / Taetle, Raymond; Aickin, Mikel; Panda, Lita; Emerson, Julia; Denise, Roe; Thompson, Floyd; Davis, John; Trent, Jeffrey; Alberts, David.

In: Genes Chromosomes and Cancer, Vol. 25, No. 1, 05.1999, p. 46-52.

Research output: Contribution to journalArticle

Taetle, Raymond ; Aickin, Mikel ; Panda, Lita ; Emerson, Julia ; Denise, Roe ; Thompson, Floyd ; Davis, John ; Trent, Jeffrey ; Alberts, David. / Chromosome abnormalities in ovarian adenocarcinoma : II. Prognostic impact of nonrandom chromosome abnormalities in 244 cases. In: Genes Chromosomes and Cancer. 1999 ; Vol. 25, No. 1. pp. 46-52.
@article{6836fed77ea0436c95339e063567875f,
title = "Chromosome abnormalities in ovarian adenocarcinoma: II. Prognostic impact of nonrandom chromosome abnormalities in 244 cases",
abstract = "In a large series of ovarian carcinomas from 244 patients, 134 cases had chromosome rearrangements. We showed before that the pattern of chromosome breakpoints involved 21 separate chromosome regions nonrandomly and, in 90{\%} of cases with breaks, the breakpoints occurred within 13 commonly involved regions. Log-rank and proportional hazards regression analyses showed that the aggregate presence of a chromosome breakpoint in any of 21 nonrandomly involved regions and breaks in 9 distinct regions (1p1, 1q2, 1p3, 3p1, 6p2, 11p1, 11q1, 12q2, and 13p1) were associated with reduced patient survival. Breakpoints in other areas of the genome, including other nonrandomly involved regions, were not associated with decreased survival. Because many cases had breakpoints in more than one nonrandomly involved region, proportional hazards regression was also used to analyze for effects of each nonrandomly involved region, controlling for effects of other regions. With this approach, only breakpoints within Ip1 and 3p1 retained independent, deleterious effects on survival. Similarly, when nonrandomly involved regions were entered into a proportional hazards model containing clinical variables associated with altered patient survival (tumor grade, tumor stage, and residual disease > 1 cm after resection), only 1 p1 (P = 0.007) and 3p1 (P = 0.04) were associated with independent, negative effects on survival. These studies demonstrate that chromosome breakpoints within specific, nonrandomly involved chromosome regions are associated with impaired survival in ovarian cancers. Regions 1p1 and 3p1 are identified as areas of particular significance and are appropriate targets for analytical techniques such as SAGE and microarray analysis.",
author = "Raymond Taetle and Mikel Aickin and Lita Panda and Julia Emerson and Roe Denise and Floyd Thompson and John Davis and Jeffrey Trent and David Alberts",
year = "1999",
month = "5",
doi = "10.1002/(SICI)1098-2264(199905)25:1<46::AID-GCC7>3.0.CO;2-O",
language = "English (US)",
volume = "25",
pages = "46--52",
journal = "Genes Chromosomes and Cancer",
issn = "1045-2257",
publisher = "Wiley-Liss Inc.",
number = "1",

}

TY - JOUR

T1 - Chromosome abnormalities in ovarian adenocarcinoma

T2 - II. Prognostic impact of nonrandom chromosome abnormalities in 244 cases

AU - Taetle, Raymond

AU - Aickin, Mikel

AU - Panda, Lita

AU - Emerson, Julia

AU - Denise, Roe

AU - Thompson, Floyd

AU - Davis, John

AU - Trent, Jeffrey

AU - Alberts, David

PY - 1999/5

Y1 - 1999/5

N2 - In a large series of ovarian carcinomas from 244 patients, 134 cases had chromosome rearrangements. We showed before that the pattern of chromosome breakpoints involved 21 separate chromosome regions nonrandomly and, in 90% of cases with breaks, the breakpoints occurred within 13 commonly involved regions. Log-rank and proportional hazards regression analyses showed that the aggregate presence of a chromosome breakpoint in any of 21 nonrandomly involved regions and breaks in 9 distinct regions (1p1, 1q2, 1p3, 3p1, 6p2, 11p1, 11q1, 12q2, and 13p1) were associated with reduced patient survival. Breakpoints in other areas of the genome, including other nonrandomly involved regions, were not associated with decreased survival. Because many cases had breakpoints in more than one nonrandomly involved region, proportional hazards regression was also used to analyze for effects of each nonrandomly involved region, controlling for effects of other regions. With this approach, only breakpoints within Ip1 and 3p1 retained independent, deleterious effects on survival. Similarly, when nonrandomly involved regions were entered into a proportional hazards model containing clinical variables associated with altered patient survival (tumor grade, tumor stage, and residual disease > 1 cm after resection), only 1 p1 (P = 0.007) and 3p1 (P = 0.04) were associated with independent, negative effects on survival. These studies demonstrate that chromosome breakpoints within specific, nonrandomly involved chromosome regions are associated with impaired survival in ovarian cancers. Regions 1p1 and 3p1 are identified as areas of particular significance and are appropriate targets for analytical techniques such as SAGE and microarray analysis.

AB - In a large series of ovarian carcinomas from 244 patients, 134 cases had chromosome rearrangements. We showed before that the pattern of chromosome breakpoints involved 21 separate chromosome regions nonrandomly and, in 90% of cases with breaks, the breakpoints occurred within 13 commonly involved regions. Log-rank and proportional hazards regression analyses showed that the aggregate presence of a chromosome breakpoint in any of 21 nonrandomly involved regions and breaks in 9 distinct regions (1p1, 1q2, 1p3, 3p1, 6p2, 11p1, 11q1, 12q2, and 13p1) were associated with reduced patient survival. Breakpoints in other areas of the genome, including other nonrandomly involved regions, were not associated with decreased survival. Because many cases had breakpoints in more than one nonrandomly involved region, proportional hazards regression was also used to analyze for effects of each nonrandomly involved region, controlling for effects of other regions. With this approach, only breakpoints within Ip1 and 3p1 retained independent, deleterious effects on survival. Similarly, when nonrandomly involved regions were entered into a proportional hazards model containing clinical variables associated with altered patient survival (tumor grade, tumor stage, and residual disease > 1 cm after resection), only 1 p1 (P = 0.007) and 3p1 (P = 0.04) were associated with independent, negative effects on survival. These studies demonstrate that chromosome breakpoints within specific, nonrandomly involved chromosome regions are associated with impaired survival in ovarian cancers. Regions 1p1 and 3p1 are identified as areas of particular significance and are appropriate targets for analytical techniques such as SAGE and microarray analysis.

UR - http://www.scopus.com/inward/record.url?scp=0032913524&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032913524&partnerID=8YFLogxK

U2 - 10.1002/(SICI)1098-2264(199905)25:1<46::AID-GCC7>3.0.CO;2-O

DO - 10.1002/(SICI)1098-2264(199905)25:1<46::AID-GCC7>3.0.CO;2-O

M3 - Article

C2 - 10221339

AN - SCOPUS:0032913524

VL - 25

SP - 46

EP - 52

JO - Genes Chromosomes and Cancer

JF - Genes Chromosomes and Cancer

SN - 1045-2257

IS - 1

ER -