TY - JOUR
T1 - Chromosome abnormalities in malignant melanoma
T2 - Clinical significance of nonrandom chromosome abnormalities in 206 cases
AU - Nelson, Mark A.
AU - Radmacher, Michael D.
AU - Simon, Richard
AU - Aickin, Mikel
AU - Yang, Jin Ming
AU - Panda, Lita
AU - Emerson, Julia
AU - Roe, Denise
AU - Adair, Lawrence
AU - Thompson, Floyd
AU - Bangert, Jerry
AU - Leong, Stanley P.L.
AU - Taetle, Raymond
AU - Salmon, Sydney
AU - Trent, Jeffrey
N1 - Funding Information:
We also with to acknowledge the many physicians providing specimens and data for this study. This work supported by CA41183, NIH-ES-95-32, CA23074, and CA 70145.
PY - 2000/10/15
Y1 - 2000/10/15
N2 - We report the cytogenetic abnormalities from a series of 206 primary malignant melanoma specimens referred to a single institution. A total of 169 out of 206 unique cases had chromosome breakpoints. A previously described statistical method was used to detect nonrandom distribution of chromosome breakpoints at the level of chromosome regions. Nonrandom occurrence of chromosome breakpoints (indicating that the observed number of breaks significantly exceeded the expected number of breaks) was detected in 28 regions, suggesting a hierarchy of genetic abnormalities in melanoma. Clinical variables and tumor characteristics were analyzed for associations with the presence of any nonrandom chromosome breakpoints; with individual, nonrandomly involved chromosome regions; and with paired, nonrandomly involved chromosome regions. No nonrandomly involved chromosome regions or pairs of regions appeared to significantly affect survival. These results identify recurring, nonrandom chromosome abnormalities in malignant melanoma. These results suggest that recurring, nonrandom chromosome alterations play a key role in the etiology and/or progression of malignant melanoma and identify targets within the genome for molecular genetic studies. (C) 2000 Elsevier Science Inc.
AB - We report the cytogenetic abnormalities from a series of 206 primary malignant melanoma specimens referred to a single institution. A total of 169 out of 206 unique cases had chromosome breakpoints. A previously described statistical method was used to detect nonrandom distribution of chromosome breakpoints at the level of chromosome regions. Nonrandom occurrence of chromosome breakpoints (indicating that the observed number of breaks significantly exceeded the expected number of breaks) was detected in 28 regions, suggesting a hierarchy of genetic abnormalities in melanoma. Clinical variables and tumor characteristics were analyzed for associations with the presence of any nonrandom chromosome breakpoints; with individual, nonrandomly involved chromosome regions; and with paired, nonrandomly involved chromosome regions. No nonrandomly involved chromosome regions or pairs of regions appeared to significantly affect survival. These results identify recurring, nonrandom chromosome abnormalities in malignant melanoma. These results suggest that recurring, nonrandom chromosome alterations play a key role in the etiology and/or progression of malignant melanoma and identify targets within the genome for molecular genetic studies. (C) 2000 Elsevier Science Inc.
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U2 - 10.1016/S0165-4608(00)00281-8
DO - 10.1016/S0165-4608(00)00281-8
M3 - Article
C2 - 11106819
AN - SCOPUS:0034667246
SN - 0165-4608
VL - 122
SP - 101
EP - 109
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 2
ER -