Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum

M. J. Gardner; H. Tettelin; D. J. Carucci; L. M. Cummings; L. Aravind; E. V. Koonin; S. Shallom; T. Mason; K. Yu; C. Fujii; J. Pederson; K. Shen; J. Jing; C. Aston; Z. Lai; D. C. Schwartz; M. Pertea; S. Salzberg; L. Zhou; G. G. Sutton; R. Clayton; O. White; H. O. Smith; C. M. Fraser; M. D. Adams; J. C. Venter; S. L. Hoffman

Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum

M. J. Gardner, H. Tettelin, D. J. Carucci, L. M. Cummings, L. Aravind, E. V. Koonin, S. Shallom, T. Mason, K. Yu, C. Fujii, J. Pederson, K. Shen, J. Jing, C. Aston, Z. Lai, D. C. Schwartz, M. Pertea, S. Salzberg, L. Zhou, G. G. SuttonR. Clayton, O. White, H. O. Smith, C. M. Fraser, M. D. Adams, J. C. Venter, S. L. Hoffman

School of Medicine

Research output: Contribution to journal › Article › peer-review

396 Scopus citations

Abstract

Chromosome 2 of Plasmodium falciparum was sequenced; this sequence contains 947,103 base pairs and encodes 210 predicted genes. In comparison with the Saccharomyces cerevisiae genome, chromosome 2 has a lower gene density, introns are more frequent, and proteins are markedly enriched in nonglobular domains. A family of surface proteins, rifins, that may play a role in antigenic variation was identified. The complete sequencing of chromosome 2 has shown that sequencing of the A+T-rich P. falciparum genome is technically feasible.

Original language	English (US)
Pages (from-to)	1126-1132
Number of pages	7
Journal	Science
Volume	282
Issue number	5391
State	Published - Nov 6 1998

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Gardner, M. J., Tettelin, H., Carucci, D. J., Cummings, L. M., Aravind, L., Koonin, E. V., Shallom, S., Mason, T., Yu, K., Fujii, C., Pederson, J., Shen, K., Jing, J., Aston, C., Lai, Z., Schwartz, D. C., Pertea, M., Salzberg, S., Zhou, L., ... Hoffman, S. L. (1998). Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Science, 282(5391), 1126-1132.

Gardner, MJ, Tettelin, H, Carucci, DJ, Cummings, LM, Aravind, L, Koonin, EV, Shallom, S, Mason, T, Yu, K, Fujii, C, Pederson, J, Shen, K, Jing, J, Aston, C, Lai, Z, Schwartz, DC, Pertea, M , Salzberg, S, Zhou, L, Sutton, GG, Clayton, R, White, O, Smith, HO, Fraser, CM, Adams, MD, Venter, JC & Hoffman, SL 1998, 'Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum', Science, vol. 282, no. 5391, pp. 1126-1132.

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title = "Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum",

abstract = "Chromosome 2 of Plasmodium falciparum was sequenced; this sequence contains 947,103 base pairs and encodes 210 predicted genes. In comparison with the Saccharomyces cerevisiae genome, chromosome 2 has a lower gene density, introns are more frequent, and proteins are markedly enriched in nonglobular domains. A family of surface proteins, rifins, that may play a role in antigenic variation was identified. The complete sequencing of chromosome 2 has shown that sequencing of the A+T-rich P. falciparum genome is technically feasible.",

author = "Gardner, {M. J.} and H. Tettelin and Carucci, {D. J.} and Cummings, {L. M.} and L. Aravind and Koonin, {E. V.} and S. Shallom and T. Mason and K. Yu and C. Fujii and J. Pederson and K. Shen and J. Jing and C. Aston and Z. Lai and Schwartz, {D. C.} and M. Pertea and S. Salzberg and L. Zhou and Sutton, {G. G.} and R. Clayton and O. White and Smith, {H. O.} and Fraser, {C. M.} and Adams, {M. D.} and Venter, {J. C.} and Hoffman, {S. L.}",

year = "1998",

month = nov,

day = "6",

language = "English (US)",

volume = "282",

pages = "1126--1132",

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T1 - Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum

AU - Gardner, M. J.

AU - Tettelin, H.

AU - Carucci, D. J.

AU - Cummings, L. M.

AU - Aravind, L.

AU - Koonin, E. V.

AU - Shallom, S.

AU - Mason, T.

AU - Yu, K.

AU - Fujii, C.

AU - Pederson, J.

AU - Shen, K.

AU - Jing, J.

AU - Aston, C.

AU - Lai, Z.

AU - Schwartz, D. C.

AU - Pertea, M.

AU - Salzberg, S.

AU - Zhou, L.

AU - Sutton, G. G.

AU - Clayton, R.

AU - White, O.

AU - Smith, H. O.

AU - Fraser, C. M.

AU - Adams, M. D.

AU - Venter, J. C.

AU - Hoffman, S. L.

PY - 1998/11/6

Y1 - 1998/11/6

N2 - Chromosome 2 of Plasmodium falciparum was sequenced; this sequence contains 947,103 base pairs and encodes 210 predicted genes. In comparison with the Saccharomyces cerevisiae genome, chromosome 2 has a lower gene density, introns are more frequent, and proteins are markedly enriched in nonglobular domains. A family of surface proteins, rifins, that may play a role in antigenic variation was identified. The complete sequencing of chromosome 2 has shown that sequencing of the A+T-rich P. falciparum genome is technically feasible.

AB - Chromosome 2 of Plasmodium falciparum was sequenced; this sequence contains 947,103 base pairs and encodes 210 predicted genes. In comparison with the Saccharomyces cerevisiae genome, chromosome 2 has a lower gene density, introns are more frequent, and proteins are markedly enriched in nonglobular domains. A family of surface proteins, rifins, that may play a role in antigenic variation was identified. The complete sequencing of chromosome 2 has shown that sequencing of the A+T-rich P. falciparum genome is technically feasible.

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JF - Science

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ER -

Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum

Abstract

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