Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum

M. J. Gardner, H. Tettelin, D. J. Carucci, L. M. Cummings, L. Aravind, E. V. Koonin, S. Shallom, T. Mason, K. Yu, C. Fujii, J. Pederson, K. Shen, J. Jing, C. Aston, Z. Lai, D. C. Schwartz, M. Pertea, S. Salzberg, L. Zhou, G. G. SuttonR. Clayton, O. White, H. O. Smith, C. M. Fraser, M. D. Adams, J. C. Venter, S. L. Hoffman

Research output: Contribution to journalArticle

Abstract

Chromosome 2 of Plasmodium falciparum was sequenced; this sequence contains 947,103 base pairs and encodes 210 predicted genes. In comparison with the Saccharomyces cerevisiae genome, chromosome 2 has a lower gene density, introns are more frequent, and proteins are markedly enriched in nonglobular domains. A family of surface proteins, rifins, that may play a role in antigenic variation was identified. The complete sequencing of chromosome 2 has shown that sequencing of the A+T-rich P. falciparum genome is technically feasible.

Original languageEnglish (US)
Pages (from-to)1126-1132
Number of pages7
JournalScience
Volume282
Issue number5391
StatePublished - Nov 6 1998

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Cite this

Gardner, M. J., Tettelin, H., Carucci, D. J., Cummings, L. M., Aravind, L., Koonin, E. V., Shallom, S., Mason, T., Yu, K., Fujii, C., Pederson, J., Shen, K., Jing, J., Aston, C., Lai, Z., Schwartz, D. C., Pertea, M., Salzberg, S., Zhou, L., ... Hoffman, S. L. (1998). Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Science, 282(5391), 1126-1132.