TY - JOUR
T1 - Chromosomal rearrangements in Barrett's esophagus. A premalignant lesion of esophageal adenocarcinoma
AU - Garewal, Harinder S.
AU - Sampliner, Richard
AU - Liu, Yun
AU - Trent, Jeffrey M.
N1 - Funding Information:
This work was supported in part by USPHS grants PO1-CA-27502 (H. G.) and CA-41183 (J. T.). H. G. is a recipient of an American Cancer Society Career Development Award. The authors acknowledge the excellent technical assistance of Floyd Thompson and Ann Burgess.
PY - 1989/10/15
Y1 - 1989/10/15
N2 - Cytogenetic analysis of 15 short-term cultures of Barrett's esophagus were investigated. In five cases, the number of metaphases identified were insufficient for analysis. Of the remaining ten cases, nine contained clonal chromosome abnormalities. Of these nine cases, one demonstrated a structural chromosome rearrangement, t(3;6)(q21;p23); one case demonstrated trisomy for chromosomes 5 and 7; and seven cases demonstrated loss of the Y chromosome as a clonal change. Our results demonstrate that Barrett's esophagus is frequently characterized by clonal proliferation of karyotypically abnormal cells.
AB - Cytogenetic analysis of 15 short-term cultures of Barrett's esophagus were investigated. In five cases, the number of metaphases identified were insufficient for analysis. Of the remaining ten cases, nine contained clonal chromosome abnormalities. Of these nine cases, one demonstrated a structural chromosome rearrangement, t(3;6)(q21;p23); one case demonstrated trisomy for chromosomes 5 and 7; and seven cases demonstrated loss of the Y chromosome as a clonal change. Our results demonstrate that Barrett's esophagus is frequently characterized by clonal proliferation of karyotypically abnormal cells.
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U2 - 10.1016/0165-4608(89)90096-4
DO - 10.1016/0165-4608(89)90096-4
M3 - Article
C2 - 2790761
AN - SCOPUS:0024454371
SN - 0165-4608
VL - 42
SP - 281
EP - 286
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 2
ER -