Chromosomal mapping of the human M6 genes

S. Olinsky, B. T. Loop, A. DeKosky, B. Ripepi, Weili Weng, J. Cummins, S. L. Wenger, Y. Yan, C. Lagenaur, V. Narayanan

Research output: Contribution to journalArticle

Abstract

M6 is a neuronal membrane glycoprotein that may have an important role in neural development. This molecule was initially defined by a monoclonal antibody that affected the survival of cultured cerebellar neurons and the outgrowth of neurites. The nature of the antigen was discovered by expression cDNA cloning using this monoclonal antibody. Two distinct murine M6 cDNAs (designated M6a and M6b) whose deduced amino acid sequences were remarkably similar to that of the myelin proteolipid protein were previously isolated. We have isolated partial human cDNA and genomic clones encoding M6a and M6b and have characterized them by restriction mapping, Southern hybridization with cDNA probes, and sequence analysis. We have localized these genes within the human genome by FISH (fluorescence in situ hybridization). The human M6a gene is located at 4q34, and the M6b gene is located at Xp22.2. A number of human neurological disorders have been mapped to the Xp22 region, including Aicardi syndrome (MIM 304050), Rett syndrome (MIM 312750), X-linked Charcot- Marie-Tooth neuropathy (MIM 302801), and X-linked mental retardation syndromes (MRX1, MIM 309530). This raises the possibility that a defect in the M6b gene is responsible for one of these neurological disorders.

Original languageEnglish (US)
Pages (from-to)532-536
Number of pages5
JournalGenomics
Volume33
Issue number3
DOIs
StatePublished - May 1 1996
Externally publishedYes

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Complementary DNA
Nervous System Diseases
Genes
Aicardi Syndrome
Myelin Proteolipid Protein
Monoclonal Antibodies
X-Linked Mental Retardation
Rett Syndrome
Restriction Mapping
Membrane Glycoproteins
Human Genome
Fluorescence In Situ Hybridization
Sequence Analysis
Organism Cloning
Amino Acid Sequence
Tooth
Clone Cells
Neurons
Antigens
Survival

ASJC Scopus subject areas

  • Genetics

Cite this

Olinsky, S., Loop, B. T., DeKosky, A., Ripepi, B., Weng, W., Cummins, J., ... Narayanan, V. (1996). Chromosomal mapping of the human M6 genes. Genomics, 33(3), 532-536. https://doi.org/10.1006/geno.1996.0231

Chromosomal mapping of the human M6 genes. / Olinsky, S.; Loop, B. T.; DeKosky, A.; Ripepi, B.; Weng, Weili; Cummins, J.; Wenger, S. L.; Yan, Y.; Lagenaur, C.; Narayanan, V.

In: Genomics, Vol. 33, No. 3, 01.05.1996, p. 532-536.

Research output: Contribution to journalArticle

Olinsky, S, Loop, BT, DeKosky, A, Ripepi, B, Weng, W, Cummins, J, Wenger, SL, Yan, Y, Lagenaur, C & Narayanan, V 1996, 'Chromosomal mapping of the human M6 genes', Genomics, vol. 33, no. 3, pp. 532-536. https://doi.org/10.1006/geno.1996.0231
Olinsky S, Loop BT, DeKosky A, Ripepi B, Weng W, Cummins J et al. Chromosomal mapping of the human M6 genes. Genomics. 1996 May 1;33(3):532-536. https://doi.org/10.1006/geno.1996.0231
Olinsky, S. ; Loop, B. T. ; DeKosky, A. ; Ripepi, B. ; Weng, Weili ; Cummins, J. ; Wenger, S. L. ; Yan, Y. ; Lagenaur, C. ; Narayanan, V. / Chromosomal mapping of the human M6 genes. In: Genomics. 1996 ; Vol. 33, No. 3. pp. 532-536.
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