Nonresponse to chemotherapy may result from the acquisition of multidrug resistance by malignant cells. Overexpression of the 170,000 dalton cell surface P-glycoprotein is associated with this phenotype and this appears to result from amplification of a multigene family coding for this protein. A cDNA encoding a conserved portion of P-glycoprotein has been cloned from hamster cells, and this was used in the present study to localize human P-glycoprotein gene sequences to chromosome 7q36.
|Original language||English (US)|
|Number of pages||8|
|Journal||Cancer Genetics and Cytogenetics|
|State||Published - Mar 1987|
ASJC Scopus subject areas
- Molecular Biology
- Cancer Research