Chromosomal location of human P-glycoprotein gene sequences

David R. Bell; Jeffrey M. Trent; Huntington F. Willard; John R. Riordan; Victor Ling

doi:10.1016/0165-4608(87)90169-5

Chromosomal location of human P-glycoprotein gene sequences

David R. Bell, Jeffrey M. Trent, Huntington F. Willard, John R. Riordan, Victor Ling

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Nonresponse to chemotherapy may result from the acquisition of multidrug resistance by malignant cells. Overexpression of the 170,000 dalton cell surface P-glycoprotein is associated with this phenotype and this appears to result from amplification of a multigene family coding for this protein. A cDNA encoding a conserved portion of P-glycoprotein has been cloned from hamster cells, and this was used in the present study to localize human P-glycoprotein gene sequences to chromosome 7q36.

Original language	English (US)
Pages (from-to)	141-148
Number of pages	8
Journal	Cancer Genetics and Cytogenetics
Volume	25
Issue number	1
DOIs	https://doi.org/10.1016/0165-4608(87)90169-5
State	Published - Mar 1987
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

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abstract = "Nonresponse to chemotherapy may result from the acquisition of multidrug resistance by malignant cells. Overexpression of the 170,000 dalton cell surface P-glycoprotein is associated with this phenotype and this appears to result from amplification of a multigene family coding for this protein. A cDNA encoding a conserved portion of P-glycoprotein has been cloned from hamster cells, and this was used in the present study to localize human P-glycoprotein gene sequences to chromosome 7q36.",

author = "Bell, {David R.} and Trent, {Jeffrey M.} and Willard, {Huntington F.} and Riordan, {John R.} and Victor Ling",

year = "1987",

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AU - Bell, David R.

AU - Trent, Jeffrey M.

AU - Willard, Huntington F.

AU - Riordan, John R.

AU - Ling, Victor

PY - 1987/3

Y1 - 1987/3

N2 - Nonresponse to chemotherapy may result from the acquisition of multidrug resistance by malignant cells. Overexpression of the 170,000 dalton cell surface P-glycoprotein is associated with this phenotype and this appears to result from amplification of a multigene family coding for this protein. A cDNA encoding a conserved portion of P-glycoprotein has been cloned from hamster cells, and this was used in the present study to localize human P-glycoprotein gene sequences to chromosome 7q36.

AB - Nonresponse to chemotherapy may result from the acquisition of multidrug resistance by malignant cells. Overexpression of the 170,000 dalton cell surface P-glycoprotein is associated with this phenotype and this appears to result from amplification of a multigene family coding for this protein. A cDNA encoding a conserved portion of P-glycoprotein has been cloned from hamster cells, and this was used in the present study to localize human P-glycoprotein gene sequences to chromosome 7q36.

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Chromosomal location of human P-glycoprotein gene sequences

Abstract

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