Chromosomal location of human P-glycoprotein gene sequences

David R. Bell, Jeffrey M. Trent, Huntington F. Willard, John R. Riordan, Victor Ling

Research output: Contribution to journalArticle

Abstract

Nonresponse to chemotherapy may result from the acquisition of multidrug resistance by malignant cells. Overexpression of the 170,000 dalton cell surface P-glycoprotein is associated with this phenotype and this appears to result from amplification of a multigene family coding for this protein. A cDNA encoding a conserved portion of P-glycoprotein has been cloned from hamster cells, and this was used in the present study to localize human P-glycoprotein gene sequences to chromosome 7q36.

Original languageEnglish (US)
Pages (from-to)141-148
Number of pages8
JournalCancer Genetics and Cytogenetics
Volume25
Issue number1
DOIs
StatePublished - Mar 1987

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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    Bell, D. R., Trent, J. M., Willard, H. F., Riordan, J. R., & Ling, V. (1987). Chromosomal location of human P-glycoprotein gene sequences. Cancer Genetics and Cytogenetics, 25(1), 141-148. https://doi.org/10.1016/0165-4608(87)90169-5