Chromosomal localization of human leukocyte, fibroblast, and immune interferon genes by means of in situ hybridization

J. M. Trent; S. Olson; R. M. Lawn

doi:10.1073/pnas.79.24.7809

Chromosomal localization of human leukocyte, fibroblast, and immune interferon genes by means of in situ hybridization

J. M. Trent, S. Olson, R. M. Lawn

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Abstract

Recombinant plasmids containing cDNA inserts from human leukocyte interferon (IFN-α), fibroblast interferon (IFN-β), or immune interferon (INF-γ) genes were radiolabeled and hybridized in situ to human metaphase chromosome preparations. The results localized the human IFN-α and IFN-β genes to the short arm of chromosome 9(p21→pter) and localized the IFN-γ gene to the long arm of chromosome 12(q24.1).

Original language	English (US)
Pages (from-to)	7809-7813
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	79
Issue number	24 I
DOIs	https://doi.org/10.1073/pnas.79.24.7809
State	Published - 1982
Externally published	Yes

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abstract = "Recombinant plasmids containing cDNA inserts from human leukocyte interferon (IFN-α), fibroblast interferon (IFN-β), or immune interferon (INF-γ) genes were radiolabeled and hybridized in situ to human metaphase chromosome preparations. The results localized the human IFN-α and IFN-β genes to the short arm of chromosome 9(p21→pter) and localized the IFN-γ gene to the long arm of chromosome 12(q24.1).",

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year = "1982",

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T1 - Chromosomal localization of human leukocyte, fibroblast, and immune interferon genes by means of in situ hybridization

AU - Trent, J. M.

AU - Olson, S.

AU - Lawn, R. M.

PY - 1982

Y1 - 1982

N2 - Recombinant plasmids containing cDNA inserts from human leukocyte interferon (IFN-α), fibroblast interferon (IFN-β), or immune interferon (INF-γ) genes were radiolabeled and hybridized in situ to human metaphase chromosome preparations. The results localized the human IFN-α and IFN-β genes to the short arm of chromosome 9(p21→pter) and localized the IFN-γ gene to the long arm of chromosome 12(q24.1).

AB - Recombinant plasmids containing cDNA inserts from human leukocyte interferon (IFN-α), fibroblast interferon (IFN-β), or immune interferon (INF-γ) genes were radiolabeled and hybridized in situ to human metaphase chromosome preparations. The results localized the human IFN-α and IFN-β genes to the short arm of chromosome 9(p21→pter) and localized the IFN-γ gene to the long arm of chromosome 12(q24.1).

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JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 24 I

ER -

Chromosomal localization of human leukocyte, fibroblast, and immune interferon genes by means of in situ hybridization

Abstract

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