Chromosomal localization of human leukocyte, fibroblast, and immune interferon genes by means of in situ hybridization

J. M. Trent, S. Olson, R. M. Lawn

Research output: Contribution to journalArticle

Abstract

Recombinant plasmids containing cDNA inserts from human leukocyte interferon (IFN-α), fibroblast interferon (IFN-β), or immune interferon (INF-γ) genes were radiolabeled and hybridized in situ to human metaphase chromosome preparations. The results localized the human IFN-α and IFN-β genes to the short arm of chromosome 9(p21→pter) and localized the IFN-γ gene to the long arm of chromosome 12(q24.1).

Original languageEnglish (US)
Pages (from-to)7809-7813
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume79
Issue number24 I
StatePublished - 1982
Externally publishedYes

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Interferon-beta
Interferon-alpha
Interferons
Interferon-gamma
In Situ Hybridization
Genes
Chromosomes, Human, Pair 12
Chromosomes, Human, Pair 9
Human Chromosomes
Metaphase
Plasmids
Complementary DNA

ASJC Scopus subject areas

  • General
  • Genetics

Cite this

Chromosomal localization of human leukocyte, fibroblast, and immune interferon genes by means of in situ hybridization. / Trent, J. M.; Olson, S.; Lawn, R. M.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 79, No. 24 I, 1982, p. 7809-7813.

Research output: Contribution to journalArticle

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