Chromosomal localization of human leukocyte, fibroblast, and immune interferon genes by means of in situ hybridization

J. M. Trent, S. Olson, R. M. Lawn

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Abstract

Recombinant plasmids containing cDNA inserts from human leukocyte interferon (IFN-α), fibroblast interferon (IFN-β), or immune interferon (INF-γ) genes were radiolabeled and hybridized in situ to human metaphase chromosome preparations. The results localized the human IFN-α and IFN-β genes to the short arm of chromosome 9(p21→pter) and localized the IFN-γ gene to the long arm of chromosome 12(q24.1).

Original languageEnglish (US)
Pages (from-to)7809-7813
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume79
Issue number24 I
DOIs
StatePublished - Jan 1 1982

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