Chromosomal localization of genes required for the terminal steps of oxidative metabolism

α and γ subunits of ATP synthase and the phosphate carrier

Ethylin Wang Jabs, Philip J. Thomas, Michael T. Bernstein, Cathleen Coss, Gloria C. Ferreira, Peter L Pedersen

Research output: Contribution to journalArticle

Abstract

The terminal steps of oxidative phosphorylation include transport of phosphate and ADP into the mitochondrial matrix, synthesis of ATP in the matrix, and transport of the product ATP into the cytosol where it can be utilized to perform cellular work. Three nuclear genome encoded membrane proteins, namely, the phosphate carrier (PHC), the adenine nucleotide carrier (ANT), and the ATP synthase complex, consisting of at least 13 individual subunits, catalyze these reactions. The locations of the α and γ subunits of the mitochondrial ATP synthase complex and the mitochondrial phosphate carrier, PHC, on human chromosomes were determined using cloned rat liver cDNA as probes. Human homologues of the α subunit are on chromosomes 9 and 18, the γ subunit are on chromosomes 10 and 14, and the PHC was localized to chromosome 12.

Original languageEnglish (US)
Pages (from-to)600-602
Number of pages3
JournalHuman Genetics
Volume93
Issue number5
DOIs
StatePublished - May 1994

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Phosphate Transport Proteins
Adenosine Triphosphate
Genes
Mitochondrial Proton-Translocating ATPases
Chromosomes, Human, Pair 18
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 12
Chromosomes, Human, Pair 10
Chromosomes, Human, Pair 9
Adenine Nucleotides
Oxidative Phosphorylation
Human Chromosomes
Cytosol
Adenosine Diphosphate
Membrane Proteins
Complementary DNA
Phosphates
Genome
Liver

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Chromosomal localization of genes required for the terminal steps of oxidative metabolism : α and γ subunits of ATP synthase and the phosphate carrier. / Jabs, Ethylin Wang; Thomas, Philip J.; Bernstein, Michael T.; Coss, Cathleen; Ferreira, Gloria C.; Pedersen, Peter L.

In: Human Genetics, Vol. 93, No. 5, 05.1994, p. 600-602.

Research output: Contribution to journalArticle

Jabs, Ethylin Wang ; Thomas, Philip J. ; Bernstein, Michael T. ; Coss, Cathleen ; Ferreira, Gloria C. ; Pedersen, Peter L. / Chromosomal localization of genes required for the terminal steps of oxidative metabolism : α and γ subunits of ATP synthase and the phosphate carrier. In: Human Genetics. 1994 ; Vol. 93, No. 5. pp. 600-602.
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