Chromoblastomycosis

Flavio Queiroz-Telles, Sybren de Hoog, Daniel Wagner C L Santos, Claudio Guedes Salgado, Vania Aparecida Vicente, Alexandro Bonifaz, Emmanuel Roilides, Liyan Xi, Conceição de Maria Pedrozo E Silva Azevedo, Moises Batista Da Silva, Zoe Dorothea Pana, Arnaldo Lopes Colombo, Thomas J. Walsh

Research output: Research - peer-reviewArticle

Abstract

Chromoblastomycosis (CBM), also known as chromomycosis, is one of the most prevalent implantation fungal infections, being the most common of the gamut of mycoses caused by melanized or brown-pigmented fungi. CBM is mainly a tropical or subtropical disease that may affect individuals with certain risk factors around the world. The following characteristics are associated with this disease: (i) traumatic inoculation by implantation from an environmental source, leading to an initial cutaneous lesion at the inoculation site; (ii) chronic and progressive cutaneous and subcutaneous tissular involvement associated with fibrotic and granulomatous reactions associated with microabscesses and often with tissue proliferation; (iii) a nonprotective T helper type 2 (Th2) immune response with ineffective humoral involvement; and (iv) the presence of muriform (sclerotic) cells embedded in the affected tissue. CBM lesions are clinically polymorphic and are commonly misdiagnosed as various other infectious and noninfectious diseases. In its more severe clinical forms, CBM may cause an incapacity for labor due to fibrotic sequelae and also due to a series of clinical complications, and if not recognized at an early stage, this disease can be refractory to antifungal therapy.

LanguageEnglish (US)
Pages233-276
Number of pages44
JournalClinical Microbiology Reviews
Volume30
Issue number1
DOIs
StatePublished - Jan 1 2017
Externally publishedYes

Fingerprint

Chromoblastomycosis
Mycoses
Skin
Diagnostic Errors
Communicable Diseases
Fungi
Therapeutics

Keywords

  • Black fungi
  • Chromoblastomycosis
  • Chromomycosis
  • Melanized fungi
  • Muriform (sclerotic) cells
  • Neglected disease

ASJC Scopus subject areas

  • Epidemiology
  • Immunology and Microbiology(all)
  • Public Health, Environmental and Occupational Health
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Queiroz-Telles, F., de Hoog, S., Santos, D. W. C. L., Salgado, C. G., Vicente, V. A., Bonifaz, A., ... Walsh, T. J. (2017). Chromoblastomycosis. Clinical Microbiology Reviews, 30(1), 233-276. DOI: 10.1128/CMR.00032-16

Chromoblastomycosis. / Queiroz-Telles, Flavio; de Hoog, Sybren; Santos, Daniel Wagner C L; Salgado, Claudio Guedes; Vicente, Vania Aparecida; Bonifaz, Alexandro; Roilides, Emmanuel; Xi, Liyan; Azevedo, Conceição de Maria Pedrozo E Silva; Da Silva, Moises Batista; Pana, Zoe Dorothea; Colombo, Arnaldo Lopes; Walsh, Thomas J.

In: Clinical Microbiology Reviews, Vol. 30, No. 1, 01.01.2017, p. 233-276.

Research output: Research - peer-reviewArticle

Queiroz-Telles, F, de Hoog, S, Santos, DWCL, Salgado, CG, Vicente, VA, Bonifaz, A, Roilides, E, Xi, L, Azevedo, CDMPES, Da Silva, MB, Pana, ZD, Colombo, AL & Walsh, TJ 2017, 'Chromoblastomycosis' Clinical Microbiology Reviews, vol 30, no. 1, pp. 233-276. DOI: 10.1128/CMR.00032-16
Queiroz-Telles F, de Hoog S, Santos DWCL, Salgado CG, Vicente VA, Bonifaz A et al. Chromoblastomycosis. Clinical Microbiology Reviews. 2017 Jan 1;30(1):233-276. Available from, DOI: 10.1128/CMR.00032-16
Queiroz-Telles, Flavio ; de Hoog, Sybren ; Santos, Daniel Wagner C L ; Salgado, Claudio Guedes ; Vicente, Vania Aparecida ; Bonifaz, Alexandro ; Roilides, Emmanuel ; Xi, Liyan ; Azevedo, Conceição de Maria Pedrozo E Silva ; Da Silva, Moises Batista ; Pana, Zoe Dorothea ; Colombo, Arnaldo Lopes ; Walsh, Thomas J./ Chromoblastomycosis. In: Clinical Microbiology Reviews. 2017 ; Vol. 30, No. 1. pp. 233-276
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