Chromatographic modeling of the release of particle-adsorbed molecules into synthetic alveolar surfactant

S. S. Sehnert, Terence H Risby

Research output: Contribution to journalArticle

Abstract

Pseudophase liquid chromatography was used to measure the thermodynamic parameters governing adsorption of organic molecules from the surfaces of carbonaceous particles into liposomal zwitterionic mobile phases. These mobile phases contain many of the important physicochemical parameters of alveolar surfactant. Results show that physical desorption into model surfactant will be dependent upon the heat of solution and the heat of adsorption. Dominance of either thermodynamic parameter is dependent upon the relative polarity of the adsorbent surface and the adsorbate molecule. It is postulated from data obtained from simple molecules containing relevant organic functional groups that physical desorption of environmental agents from the surfaces of particulate complexes into alveolar surfactant may be predicted both by quantification of the polarity of the system and of the extent of surface coverage under investigation.

Original languageEnglish (US)
Pages (from-to)185-195
Number of pages11
JournalEnvironmental Health Perspectives
Volume78
StatePublished - 1988

Fingerprint

Surface-Active Agents
surfactant
Thermodynamics
Adsorption
Molecules
Hot Temperature
modeling
Desorption
desorption
thermodynamics
adsorption
Liquid Chromatography
Liquid chromatography
Adsorbates
Adsorbents
Functional groups
functional group
liquid chromatography
particle
parameter

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Public Health, Environmental and Occupational Health

Cite this

@article{95f73cabe7654e91a831ee391da593a5,
title = "Chromatographic modeling of the release of particle-adsorbed molecules into synthetic alveolar surfactant",
abstract = "Pseudophase liquid chromatography was used to measure the thermodynamic parameters governing adsorption of organic molecules from the surfaces of carbonaceous particles into liposomal zwitterionic mobile phases. These mobile phases contain many of the important physicochemical parameters of alveolar surfactant. Results show that physical desorption into model surfactant will be dependent upon the heat of solution and the heat of adsorption. Dominance of either thermodynamic parameter is dependent upon the relative polarity of the adsorbent surface and the adsorbate molecule. It is postulated from data obtained from simple molecules containing relevant organic functional groups that physical desorption of environmental agents from the surfaces of particulate complexes into alveolar surfactant may be predicted both by quantification of the polarity of the system and of the extent of surface coverage under investigation.",
author = "Sehnert, {S. S.} and Risby, {Terence H}",
year = "1988",
language = "English (US)",
volume = "78",
pages = "185--195",
journal = "Environmental Health Perspectives",
issn = "0091-6765",
publisher = "Public Health Services, US Dept of Health and Human Services",

}

TY - JOUR

T1 - Chromatographic modeling of the release of particle-adsorbed molecules into synthetic alveolar surfactant

AU - Sehnert, S. S.

AU - Risby, Terence H

PY - 1988

Y1 - 1988

N2 - Pseudophase liquid chromatography was used to measure the thermodynamic parameters governing adsorption of organic molecules from the surfaces of carbonaceous particles into liposomal zwitterionic mobile phases. These mobile phases contain many of the important physicochemical parameters of alveolar surfactant. Results show that physical desorption into model surfactant will be dependent upon the heat of solution and the heat of adsorption. Dominance of either thermodynamic parameter is dependent upon the relative polarity of the adsorbent surface and the adsorbate molecule. It is postulated from data obtained from simple molecules containing relevant organic functional groups that physical desorption of environmental agents from the surfaces of particulate complexes into alveolar surfactant may be predicted both by quantification of the polarity of the system and of the extent of surface coverage under investigation.

AB - Pseudophase liquid chromatography was used to measure the thermodynamic parameters governing adsorption of organic molecules from the surfaces of carbonaceous particles into liposomal zwitterionic mobile phases. These mobile phases contain many of the important physicochemical parameters of alveolar surfactant. Results show that physical desorption into model surfactant will be dependent upon the heat of solution and the heat of adsorption. Dominance of either thermodynamic parameter is dependent upon the relative polarity of the adsorbent surface and the adsorbate molecule. It is postulated from data obtained from simple molecules containing relevant organic functional groups that physical desorption of environmental agents from the surfaces of particulate complexes into alveolar surfactant may be predicted both by quantification of the polarity of the system and of the extent of surface coverage under investigation.

UR - http://www.scopus.com/inward/record.url?scp=0023813867&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023813867&partnerID=8YFLogxK

M3 - Article

C2 - 3203638

AN - SCOPUS:0023813867

VL - 78

SP - 185

EP - 195

JO - Environmental Health Perspectives

JF - Environmental Health Perspectives

SN - 0091-6765

ER -