Choroidal neovascularization in caucasian patients with longstanding central serous chorioretinopathy

Enrico Peiretti, Daniela C. Ferrara, Giulia Caminiti, Marco Mura, John Hughes

Research output: Contribution to journalArticle

Abstract

Purpose: To report the frequency of choroidal neovascularization (CNV) in Caucasian patients with chronic central serous chorioretinopathy (CSC). Methods: Retrospective consecutive series of 272 eyes (136 patients) who were diagnosed as having chronic CSC based on clinical and multimodal fundus imaging findings and documented disease activity for at least 6 months. The CNVs were mainly determined by indocyanine-green angiography. Results: Patients were evaluated and followed for a maximum of 6 years, with an average follow-up of 14 ± 12 months. Distinct CNV was identified in 41 eyes (34 patients). Based on fluorescein angiography, 37 eyes showed occult with no classic CNV, 3 eyes showed predominantly classic and 1 eye had a disciform CNV. Furthermore, indocyaninegreen angiography revealed polypoidal choroidal vasculopathy lesions, in 27 of the 37 eyes, classified as occult CNV on fluorescein angiography. In total, 17.6% of our patients with chronic CSC were found to have CNV that upon indocyanine-green angiography were recognized as being polypoidal choroidal vasculopathy. Conclusion: In our series of Caucasian patients, we found a significant correlation between chronic CSC and CNV, in which the majority of patients with CNV were found to have polypoidal choroidal vasculopathy. Our findings suggest that indocyanine-green angiography is an indispensable tool in the investigation of chronic CSC.

Original languageEnglish (US)
Pages (from-to)1360-1367
Number of pages8
JournalRetina
Volume35
Issue number7
StatePublished - 2015
Externally publishedYes

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Central Serous Chorioretinopathy
Choroidal Neovascularization
Indocyanine Green
Angiography
Fluorescein Angiography
Multimodal Imaging

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Peiretti, E., Ferrara, D. C., Caminiti, G., Mura, M., & Hughes, J. (2015). Choroidal neovascularization in caucasian patients with longstanding central serous chorioretinopathy. Retina, 35(7), 1360-1367.

Choroidal neovascularization in caucasian patients with longstanding central serous chorioretinopathy. / Peiretti, Enrico; Ferrara, Daniela C.; Caminiti, Giulia; Mura, Marco; Hughes, John.

In: Retina, Vol. 35, No. 7, 2015, p. 1360-1367.

Research output: Contribution to journalArticle

Peiretti, E, Ferrara, DC, Caminiti, G, Mura, M & Hughes, J 2015, 'Choroidal neovascularization in caucasian patients with longstanding central serous chorioretinopathy', Retina, vol. 35, no. 7, pp. 1360-1367.
Peiretti E, Ferrara DC, Caminiti G, Mura M, Hughes J. Choroidal neovascularization in caucasian patients with longstanding central serous chorioretinopathy. Retina. 2015;35(7):1360-1367.
Peiretti, Enrico ; Ferrara, Daniela C. ; Caminiti, Giulia ; Mura, Marco ; Hughes, John. / Choroidal neovascularization in caucasian patients with longstanding central serous chorioretinopathy. In: Retina. 2015 ; Vol. 35, No. 7. pp. 1360-1367.
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abstract = "Purpose: To report the frequency of choroidal neovascularization (CNV) in Caucasian patients with chronic central serous chorioretinopathy (CSC). Methods: Retrospective consecutive series of 272 eyes (136 patients) who were diagnosed as having chronic CSC based on clinical and multimodal fundus imaging findings and documented disease activity for at least 6 months. The CNVs were mainly determined by indocyanine-green angiography. Results: Patients were evaluated and followed for a maximum of 6 years, with an average follow-up of 14 ± 12 months. Distinct CNV was identified in 41 eyes (34 patients). Based on fluorescein angiography, 37 eyes showed occult with no classic CNV, 3 eyes showed predominantly classic and 1 eye had a disciform CNV. Furthermore, indocyaninegreen angiography revealed polypoidal choroidal vasculopathy lesions, in 27 of the 37 eyes, classified as occult CNV on fluorescein angiography. In total, 17.6{\%} of our patients with chronic CSC were found to have CNV that upon indocyanine-green angiography were recognized as being polypoidal choroidal vasculopathy. Conclusion: In our series of Caucasian patients, we found a significant correlation between chronic CSC and CNV, in which the majority of patients with CNV were found to have polypoidal choroidal vasculopathy. Our findings suggest that indocyanine-green angiography is an indispensable tool in the investigation of chronic CSC.",
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AB - Purpose: To report the frequency of choroidal neovascularization (CNV) in Caucasian patients with chronic central serous chorioretinopathy (CSC). Methods: Retrospective consecutive series of 272 eyes (136 patients) who were diagnosed as having chronic CSC based on clinical and multimodal fundus imaging findings and documented disease activity for at least 6 months. The CNVs were mainly determined by indocyanine-green angiography. Results: Patients were evaluated and followed for a maximum of 6 years, with an average follow-up of 14 ± 12 months. Distinct CNV was identified in 41 eyes (34 patients). Based on fluorescein angiography, 37 eyes showed occult with no classic CNV, 3 eyes showed predominantly classic and 1 eye had a disciform CNV. Furthermore, indocyaninegreen angiography revealed polypoidal choroidal vasculopathy lesions, in 27 of the 37 eyes, classified as occult CNV on fluorescein angiography. In total, 17.6% of our patients with chronic CSC were found to have CNV that upon indocyanine-green angiography were recognized as being polypoidal choroidal vasculopathy. Conclusion: In our series of Caucasian patients, we found a significant correlation between chronic CSC and CNV, in which the majority of patients with CNV were found to have polypoidal choroidal vasculopathy. Our findings suggest that indocyanine-green angiography is an indispensable tool in the investigation of chronic CSC.

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