Chorionic villus sampling for fetal Rh typing: Clinical implications

T. S. Kickler, K. Blakemore, R. S. Shirey, S. Nicol, N. Callan, P. M. Ness, C. Escallon, G. Dover

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVE: The prenatal Rh typing of red blood cells obtained by chorionic villus sampling was performed with an immune rosette technique. STUDY DESIGN: Ten Rh-negative pregnant women undergoing chorionic villus sampling at 9 to 11 weeks' gestation were studied at a large referral hospital. RESULTS: Accurate Rh phenotyping may be done on red blood cells obtained from chorionic villi weighing 2 to 8 mg. The preparations were shown to be >90% fetal in origin as demonstrated by radial immunodiffusion quantitation of fetal hemoglobin-containing cells. Of the 10 fetuses typed in the first trimester nine of the pregnancies were carried to term. In all cases typing of red blood cells confirmed the antenatal fetal red cell typing. CONCLUSIONS: This study shows that antenatal Rh phenotyping may be performed as early as 9 to 11 weeks' gestation. This technique may be used in the management of pregnancies complicated by Rh incompatibility.

Original languageEnglish (US)
Pages (from-to)1407-1411
Number of pages5
JournalAmerican journal of obstetrics and gynecology
Volume166
Issue number5
DOIs
StatePublished - May 1992

Keywords

  • Hemolytic disease of the newborn
  • chorionic villus sampling
  • prenatal diagnosis

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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