Chordoma of the Spinal Column

Daniel Sciubba, John H. Chi, Laurence D. Rhines, Ziya L. Gokaslan

Research output: Contribution to journalArticle

Abstract

Chordomas are the most common primary malignant tumor of the mobile spine and of the sacrum. Although considered not to possess significant metastatic potential, such lesions are locally aggressive, leading to neurologic compromise and lytic destruction of bone. En bloc resection has afforded patients the greatest chance of local control and disease-free survival. Such radical resections may be associated with significant surgical morbidity, however. Although considered generally resistant to radiation therapy and chemotherapy, recent advances in photon and proton radiation therapy and use of monoclonal antibodies may provide improved outcomes for poor surgical candidates and for tumors that recur after surgery.

Original languageEnglish (US)
Pages (from-to)5-15
Number of pages11
JournalNeurosurgery Clinics of North America
Volume19
Issue number1
DOIs
StatePublished - Jan 2008

Fingerprint

Chordoma
Spine
Radiotherapy
Proton Therapy
Sacrum
Photons
Nervous System
Disease-Free Survival
Neoplasms
Monoclonal Antibodies
Morbidity
Bone and Bones
Drug Therapy

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Chordoma of the Spinal Column. / Sciubba, Daniel; Chi, John H.; Rhines, Laurence D.; Gokaslan, Ziya L.

In: Neurosurgery Clinics of North America, Vol. 19, No. 1, 01.2008, p. 5-15.

Research output: Contribution to journalArticle

Sciubba, Daniel ; Chi, John H. ; Rhines, Laurence D. ; Gokaslan, Ziya L. / Chordoma of the Spinal Column. In: Neurosurgery Clinics of North America. 2008 ; Vol. 19, No. 1. pp. 5-15.
@article{47b544f0e94848259b1662cf204fbf92,
title = "Chordoma of the Spinal Column",
abstract = "Chordomas are the most common primary malignant tumor of the mobile spine and of the sacrum. Although considered not to possess significant metastatic potential, such lesions are locally aggressive, leading to neurologic compromise and lytic destruction of bone. En bloc resection has afforded patients the greatest chance of local control and disease-free survival. Such radical resections may be associated with significant surgical morbidity, however. Although considered generally resistant to radiation therapy and chemotherapy, recent advances in photon and proton radiation therapy and use of monoclonal antibodies may provide improved outcomes for poor surgical candidates and for tumors that recur after surgery.",
author = "Daniel Sciubba and Chi, {John H.} and Rhines, {Laurence D.} and Gokaslan, {Ziya L.}",
year = "2008",
month = "1",
doi = "10.1016/j.nec.2007.09.006",
language = "English (US)",
volume = "19",
pages = "5--15",
journal = "Neurosurgery Clinics of North America",
issn = "1042-3680",
publisher = "W.B. Saunders Ltd",
number = "1",

}

TY - JOUR

T1 - Chordoma of the Spinal Column

AU - Sciubba, Daniel

AU - Chi, John H.

AU - Rhines, Laurence D.

AU - Gokaslan, Ziya L.

PY - 2008/1

Y1 - 2008/1

N2 - Chordomas are the most common primary malignant tumor of the mobile spine and of the sacrum. Although considered not to possess significant metastatic potential, such lesions are locally aggressive, leading to neurologic compromise and lytic destruction of bone. En bloc resection has afforded patients the greatest chance of local control and disease-free survival. Such radical resections may be associated with significant surgical morbidity, however. Although considered generally resistant to radiation therapy and chemotherapy, recent advances in photon and proton radiation therapy and use of monoclonal antibodies may provide improved outcomes for poor surgical candidates and for tumors that recur after surgery.

AB - Chordomas are the most common primary malignant tumor of the mobile spine and of the sacrum. Although considered not to possess significant metastatic potential, such lesions are locally aggressive, leading to neurologic compromise and lytic destruction of bone. En bloc resection has afforded patients the greatest chance of local control and disease-free survival. Such radical resections may be associated with significant surgical morbidity, however. Although considered generally resistant to radiation therapy and chemotherapy, recent advances in photon and proton radiation therapy and use of monoclonal antibodies may provide improved outcomes for poor surgical candidates and for tumors that recur after surgery.

UR - http://www.scopus.com/inward/record.url?scp=37349093405&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=37349093405&partnerID=8YFLogxK

U2 - 10.1016/j.nec.2007.09.006

DO - 10.1016/j.nec.2007.09.006

M3 - Article

C2 - 18156043

AN - SCOPUS:37349093405

VL - 19

SP - 5

EP - 15

JO - Neurosurgery Clinics of North America

JF - Neurosurgery Clinics of North America

SN - 1042-3680

IS - 1

ER -