Chordoma of the Spinal Column

Daniel M. Sciubba, John H. Chi, Laurence D. Rhines, Ziya L. Gokaslan

Research output: Contribution to journalReview articlepeer-review

Abstract

Chordomas are the most common primary malignant tumor of the mobile spine and of the sacrum. Although considered not to possess significant metastatic potential, such lesions are locally aggressive, leading to neurologic compromise and lytic destruction of bone. En bloc resection has afforded patients the greatest chance of local control and disease-free survival. Such radical resections may be associated with significant surgical morbidity, however. Although considered generally resistant to radiation therapy and chemotherapy, recent advances in photon and proton radiation therapy and use of monoclonal antibodies may provide improved outcomes for poor surgical candidates and for tumors that recur after surgery.

Original languageEnglish (US)
Pages (from-to)5-15
Number of pages11
JournalNeurosurgery clinics of North America
Volume19
Issue number1
DOIs
StatePublished - Jan 1 2008

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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