@article{3e00a928e8234e48ad0c029ce3868a40,
title = "Chordoma of the sacrum and mobile spine: a narrative review",
abstract = "Chordoma is a notochord-derived primary tumor of the skull base and vertebral column known to affect 0.08 to 0.5 per 100,000 persons worldwide. Patients commonly present with mechanical, midline pain with or without radicular features secondary to nerve root compression. Management of these lesions has classically revolved around oncologic resection, defined by en bloc resection of the lesion with negative margins as this was found to significantly improve both local control and overall survival. With advancement in radiation modalities, namely the increased availability of focused photon therapy and proton beam radiation, high-dose (>50 Gy) neoadjuvant or adjuvant radiotherapy is also becoming a standard of care. At present chemotherapy does not appear to have a role, but ongoing investigations into the ontogeny and molecular pathophysiology of chordoma promise to identify therapeutic targets that may further alter this paradigm. In this narrative review we describe the epidemiology, histopathology, diagnosis, and treatment of chordoma.",
keywords = "Chordoma, Clinical guidelines, En bloc resection, Evidence-based medicine, Overall survival, Proton beam therapy, Stereotactic radiation",
author = "Zach Pennington and Jeff Ehresman and McCarthy, {Edward F.} and Ahmed, {A. Karim} and Pittman, {Patricia D.} and Daniel Lubelski and Goodwin, {C. Rory} and Sciubba, {Daniel M.}",
note = "Funding Information: Author disclosures: ZP: Nothing to disclose. JE: Nothing to disclose. EFM: Nothing to disclose. AKA: Nothing to disclose. PP: Nothing to disclose. DL: Nothing to disclose. CRG: Grant: Robert Wood Johnson Harold Amos Medical Faculty Development Program (E), Burroughs Wellcome Fund (E), the NIH/NINDS K12 NRCDP Physician Scientist Award (B). DMS: Consulting: Baxter (C), DePuy-Synthes (D), Ethicon (B), Globus Medical (B), K2M (C), Medical Devices (E), Medtronic (C), NuVasive (B), Stryker (F); Trip/Travel: Baxter (A), DePuy Synthes (B), Globus Medical (B), K2M (B), Medical Devices Inc (C), Medicrea (B), Medtronic (C), NuVasice (B), Stryker (C), Synthes (C); Grant: Baxter Medical (D), North American Spine Society (C), Stryker (E). Funding Information: Author disclosures: ZP: Nothing to disclose. JE: Nothing to disclose. EFM: Nothing to disclose. AKA: Nothing to disclose. PP: Nothing to disclose. DL: Nothing to disclose. CRG: Grant: Robert Wood Johnson Harold Amos Medical Faculty Development Program (E), Burroughs Wellcome Fund (E), the NIH/NINDS K12 NRCDP Physician Scientist Award (B). DMS: Consulting: Baxter (C), DePuy-Synthes (D), Ethicon (B), Globus Medical (B), K2M (C), Medical Devices (E), Medtronic (C), NuVasive (B), Stryker (F); Trip/Travel: Baxter (A), DePuy Synthes (B), Globus Medical (B), K2M (B), Medical Devices Inc (C), Medicrea (B), Medtronic (C), NuVasice (B), Stryker (C), Synthes (C); Grant: Baxter Medical (D), North American Spine Society (C), Stryker (E). Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2021",
month = mar,
doi = "10.1016/j.spinee.2020.10.009",
language = "English (US)",
volume = "21",
pages = "500--517",
journal = "Spine Journal",
issn = "1529-9430",
publisher = "Elsevier Inc.",
number = "3",
}