Chondrosarcoma of the spine: a narrative review

Zach Pennington, Jeff Ehresman, Patricia D. Pittman, A. Karim Ahmed, Daniel Lubelski, Edward F. McCarthy, C. Rory Goodwin, Daniel M. Sciubba

Research output: Contribution to journalReview articlepeer-review


Chondrosarcoma is an uncommon primary bone tumor with an estimated incidence of 0.5 per 100,000 patient-years. Primary chondrosarcoma of the mobile spine and sacrum cumulatively account for less than 20% of all cases, most.commonly causing patients to present with focal pain with or without radiculopathy, or myelopathy secondary to neural element compression. Because of the rarity, patients benefit from multidisciplinary care at academic tertiary-care centers. Current standard-of-care consists of en bloc surgical resection with negative margins; for high grade lesions adjuvant focused radiation with ≥60 gray equivalents is taking an increased role in improving local control. Prognosis is dictated by lesion grade at the time of resection. Several groups have put forth survival calculators and epidemiological evidence suggests prognosis is quite good for lesions receiving R0 resection. Future efforts will be focused on identifying potential chemotherapeutic adjuvants and refining radiation treatments as a means of improving local control.

Original languageEnglish (US)
Pages (from-to)2078-2096
Number of pages19
JournalSpine Journal
Issue number12
StatePublished - Dec 2021


  • Chondrosarcoma
  • Clinical guidelines
  • En bloc resection
  • Evidence-based medicine
  • Overall survival
  • Proton beam therapy
  • Stereotactic radiation

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine
  • Clinical Neurology


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