Cholinergic synaptic inhibition of inner hair cells in the neonatal mammalian cochlea

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Abstract

Efferent feedback onto sensory organs provides a means to modulate input to the central nervous system. In the developing mammalian cochlea, inner hair cells are transiently, innervated by efferent fibers, even before sensory function begins. Here, we show that neonatal inner hair cells are inhibited by cholinergic synaptic input before the onset of hearing. The synaptic currents, as well as the inner hair cells response to acetylcholine, are mediated by a nicotinic (α9-containing) receptor and result in the activation of small-conductance calcium-dependent potassium channels.

Original languageEnglish (US)
Pages (from-to)2366-2368
Number of pages3
JournalScience
Volume288
Issue number5475
DOIs
StatePublished - Jun 30 2000

ASJC Scopus subject areas

  • General

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