TY - JOUR
T1 - Cholinergic synaptic inhibition of inner hair cells in the neonatal mammalian cochlea
AU - Glowatzki, Elisabeth
AU - Fuchs, Paul A.
PY - 2000/6/30
Y1 - 2000/6/30
N2 - Efferent feedback onto sensory organs provides a means to modulate input to the central nervous system. In the developing mammalian cochlea, inner hair cells are transiently, innervated by efferent fibers, even before sensory function begins. Here, we show that neonatal inner hair cells are inhibited by cholinergic synaptic input before the onset of hearing. The synaptic currents, as well as the inner hair cells response to acetylcholine, are mediated by a nicotinic (α9-containing) receptor and result in the activation of small-conductance calcium-dependent potassium channels.
AB - Efferent feedback onto sensory organs provides a means to modulate input to the central nervous system. In the developing mammalian cochlea, inner hair cells are transiently, innervated by efferent fibers, even before sensory function begins. Here, we show that neonatal inner hair cells are inhibited by cholinergic synaptic input before the onset of hearing. The synaptic currents, as well as the inner hair cells response to acetylcholine, are mediated by a nicotinic (α9-containing) receptor and result in the activation of small-conductance calcium-dependent potassium channels.
UR - http://www.scopus.com/inward/record.url?scp=0034733668&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034733668&partnerID=8YFLogxK
U2 - 10.1126/science.288.5475.2366
DO - 10.1126/science.288.5475.2366
M3 - Article
C2 - 10875922
AN - SCOPUS:0034733668
SN - 0036-8075
VL - 288
SP - 2366
EP - 2368
JO - Science
JF - Science
IS - 5475
ER -