Cholinergic phosphatidylinositol modulation of inhibitory, G protein-linked, neutrotransmitter actions: Electrophysiological studies in rat hippocampus

P. F. Worley, J. M. Baraban, M. McCarren, S. H. Snyder, B. E. Alger

Research output: Contribution to journalArticlepeer-review

Abstract

In electrophysiological studies the rat hippocampal slice preparation, cholinergic agonists and phorbol 12,13-diacetate, a stimulator of protein kinase C, block the inhibitory actions of baclofen, a γ-aminobutyric acid B receptor agonist, and adenosine. Relative potencies of cholinergic agonists in stimulating the phosphatidylinositol system, as measured biochemically, parallel their activity in blocking adenosine assessed electrophysiologically. Electrical stimulation of cholinergic afferents also reverses adenosine's inhibitory action. These findings indicate that stimulation of protein kinase C by the phosphatidylinositol system mediates cholinergic blockade of adenosine and baclofen. As these inhibitory agonists act by way of receptors linked to GTP-binding proteins, protein kinase C's inactivation of the GTP-binding protein involved may account for this cholinergic action.

Original languageEnglish (US)
Pages (from-to)3467-3471
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume84
Issue number10
DOIs
StatePublished - 1987

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Cholinergic phosphatidylinositol modulation of inhibitory, G protein-linked, neutrotransmitter actions: Electrophysiological studies in rat hippocampus'. Together they form a unique fingerprint.

Cite this