Methylphenidate hydrochloride (1 and 2 mg/kg i.v.) markedly attenuated the discharge rates of neurones in the mcsencephalic reticular formation of immobilized rats. This effect of methyl-phenidate was mimicked by oxotremorine and nicotine, unaffected by atropine, and abolished by mecamylamine. A central action of oxotremorine and nicotine was indicated by the further finding that atropine but not methyl atropine blocked the effect of oxotremorine. and that mecamylamine but not hexamethonium blocked the effect of nicotine. These results suggest that cholinergic mechanisms might mediate the electrophysiological effect of methylphenidate in the mesencephalic reticular formation and also the therapeutic effect of this drug in hyperactive children.
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Drug Discovery