Choline acetyltransferase activity of spinal cord cell cultures is increased by diisopropylphosphorofluoridate

Neville Brookes, Alan M. Goldberg

Research output: Contribution to journalArticlepeer-review

Abstract

Diisopropylphosphorofluoridate (DFP) increased the specific activity of choline acetyltransferase (ChAT) in mouse spinal cord cell cultures but paraoxon did not, though both toxicants inhibited cholinesterase activity to a comparable extent. This effect of DFP was observed after prolonged exposure but not after short-term application to the cultures. It is postulated that this delayed effect of DFP in vitro may possibly be related tothe delayed neuropathy caused by DFP in certain species in vivo.

Original languageEnglish (US)
Pages (from-to)889-893
Number of pages5
JournalLife Sciences
Volume24
Issue number10
DOIs
StatePublished - Mar 5 1979

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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