Choline acetyltransferase activity in striatum of neonatal rats increased by nerve growth factor

William C. Mobley, J. Lynn Rutkowski, Gihan I. Tennekoon, Karen Buchanan, Michael V Johnston

Research output: Contribution to journalArticle

Abstract

Some neurodegenerative disorders may be caused by abnormal synthesis or utilization of trophic molecules required to support neuronal survival. A test of this hypothesis requires that trophic agents specific for the affected neurons be identified. Cholinergic neurons in the corpus striatum of neonatal rats were found to respond to intracerebroventricular administration of nerve growth factor with prominent, dose-dependent, selective increases in choline acetyltransferase activity. Cholinergic neurons in the basal forebrain also respond to nerve growth factor in this way. These actions of nerve growth factor may indicate its involvement in the normal function of forebrain cholinergic neurons as well as in neurodegenerative disorders involving such cells.

Original languageEnglish (US)
Pages (from-to)284-287
Number of pages4
JournalScience
Volume229
Issue number4710
StatePublished - 1985
Externally publishedYes

Fingerprint

Cholinergic Neurons
Choline O-Acetyltransferase
Nerve Growth Factor
Neurodegenerative Diseases
Corpus Striatum
Prosencephalon
Neurons

ASJC Scopus subject areas

  • General

Cite this

Mobley, W. C., Rutkowski, J. L., Tennekoon, G. I., Buchanan, K., & Johnston, M. V. (1985). Choline acetyltransferase activity in striatum of neonatal rats increased by nerve growth factor. Science, 229(4710), 284-287.

Choline acetyltransferase activity in striatum of neonatal rats increased by nerve growth factor. / Mobley, William C.; Rutkowski, J. Lynn; Tennekoon, Gihan I.; Buchanan, Karen; Johnston, Michael V.

In: Science, Vol. 229, No. 4710, 1985, p. 284-287.

Research output: Contribution to journalArticle

Mobley, WC, Rutkowski, JL, Tennekoon, GI, Buchanan, K & Johnston, MV 1985, 'Choline acetyltransferase activity in striatum of neonatal rats increased by nerve growth factor', Science, vol. 229, no. 4710, pp. 284-287.
Mobley WC, Rutkowski JL, Tennekoon GI, Buchanan K, Johnston MV. Choline acetyltransferase activity in striatum of neonatal rats increased by nerve growth factor. Science. 1985;229(4710):284-287.
Mobley, William C. ; Rutkowski, J. Lynn ; Tennekoon, Gihan I. ; Buchanan, Karen ; Johnston, Michael V. / Choline acetyltransferase activity in striatum of neonatal rats increased by nerve growth factor. In: Science. 1985 ; Vol. 229, No. 4710. pp. 284-287.
@article{1b9a4b9ea69a48aa90fae157a7d55494,
title = "Choline acetyltransferase activity in striatum of neonatal rats increased by nerve growth factor",
abstract = "Some neurodegenerative disorders may be caused by abnormal synthesis or utilization of trophic molecules required to support neuronal survival. A test of this hypothesis requires that trophic agents specific for the affected neurons be identified. Cholinergic neurons in the corpus striatum of neonatal rats were found to respond to intracerebroventricular administration of nerve growth factor with prominent, dose-dependent, selective increases in choline acetyltransferase activity. Cholinergic neurons in the basal forebrain also respond to nerve growth factor in this way. These actions of nerve growth factor may indicate its involvement in the normal function of forebrain cholinergic neurons as well as in neurodegenerative disorders involving such cells.",
author = "Mobley, {William C.} and Rutkowski, {J. Lynn} and Tennekoon, {Gihan I.} and Karen Buchanan and Johnston, {Michael V}",
year = "1985",
language = "English (US)",
volume = "229",
pages = "284--287",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "4710",

}

TY - JOUR

T1 - Choline acetyltransferase activity in striatum of neonatal rats increased by nerve growth factor

AU - Mobley, William C.

AU - Rutkowski, J. Lynn

AU - Tennekoon, Gihan I.

AU - Buchanan, Karen

AU - Johnston, Michael V

PY - 1985

Y1 - 1985

N2 - Some neurodegenerative disorders may be caused by abnormal synthesis or utilization of trophic molecules required to support neuronal survival. A test of this hypothesis requires that trophic agents specific for the affected neurons be identified. Cholinergic neurons in the corpus striatum of neonatal rats were found to respond to intracerebroventricular administration of nerve growth factor with prominent, dose-dependent, selective increases in choline acetyltransferase activity. Cholinergic neurons in the basal forebrain also respond to nerve growth factor in this way. These actions of nerve growth factor may indicate its involvement in the normal function of forebrain cholinergic neurons as well as in neurodegenerative disorders involving such cells.

AB - Some neurodegenerative disorders may be caused by abnormal synthesis or utilization of trophic molecules required to support neuronal survival. A test of this hypothesis requires that trophic agents specific for the affected neurons be identified. Cholinergic neurons in the corpus striatum of neonatal rats were found to respond to intracerebroventricular administration of nerve growth factor with prominent, dose-dependent, selective increases in choline acetyltransferase activity. Cholinergic neurons in the basal forebrain also respond to nerve growth factor in this way. These actions of nerve growth factor may indicate its involvement in the normal function of forebrain cholinergic neurons as well as in neurodegenerative disorders involving such cells.

UR - http://www.scopus.com/inward/record.url?scp=0021972462&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021972462&partnerID=8YFLogxK

M3 - Article

C2 - 2861660

AN - SCOPUS:0021972462

VL - 229

SP - 284

EP - 287

JO - Science

JF - Science

SN - 0036-8075

IS - 4710

ER -