Cholesterol, statins, and dementia: What the cardiologist should know

Brett L. Wanamaker, Kristopher J. Swiger, Roger S. Blumenthal, Seth S. Martin

Research output: Contribution to journalReview articlepeer-review

Abstract

Alzheimer dementia (AD) is an important clinical problem that appears to be closely tied to comorbid cardiovascular disease, making it a relevant topic for the clinical cardiologist. Determinants of cardiovascular health, especially midlife dyslipidemia, are associated with an increased risk of dementia based on molecular and epidemiologic data. Given the potential role of dyslipidemia in the development of dementia, statins have been investigated as potential therapeutic options to slow or prevent disease. This review discusses the role of dyslipidemia and other cardiovascular risk factors in the pathogenesis of AD, with a focus on the existing evidence for the use of statin medications in the treatment and prevention of AD from observational studies and randomized clinical trials. Clinical questions for the practicing cardiologist are addressed.

Original languageEnglish (US)
Pages (from-to)243-250
Number of pages8
JournalClinical Cardiology
Volume38
Issue number4
DOIs
StatePublished - Apr 1 2015

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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