Cholesterol homeostasis: Clipping out a slippery regulator

Research output: Contribution to journalArticle

Abstract

SREBPs are transcriptional activators central to cholesterol homeostasis. Recent work has shown that a two-step cleavage of membrane-bound SREBPs frees them to enter the nucleus. An activator of the first, sterol-regulated proteolysis step has also been identified.

Original languageEnglish (US)
Pages (from-to)R172-R174
JournalCurrent Biology
Volume7
Issue number3
DOIs
StatePublished - 1997

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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