Neonatal cholestasis or direct hyperbilirubinemia in the first 3 months of life is nearly always more pathologic than physiologic. This article reviews the extensive differential diagnosis of cholestatic jaundice and the approach to diagnosis. A sense of urgency is underscored by the value of early recognition and intervention in metabolic, iatrogenic, and anatomic disorders. The long-term management goals are reviewed, including indications for hepatic transplantation.
|Original language||English (US)|
|Journal||Clinics in Perinatology|
|Publication status||Published - Jan 1 1990|
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health