Cholestasis beyond the neonatal and infancy periods

Racha Khalaf, Claudia Phen, Sara Karjoo, Michael Wilsey

Research output: Contribution to journalReview articlepeer-review

Abstract

Cholestasis results from impairment in the excretion of bile, which may be due to mechanical obstruction of bile flow or impairment of excretion of bile components into the bile canaliculus. When present, cholestasis warrants prompt diagnosis and treatment. The differential diagnosis of cholestasis beyond the neonatal period is broad and includes congenital and acquired etiologies. It is imperative that the clinician differentiates between intrahepatic and extrahepatic origin of cholestasis. Treatment may be supportive or curative and depends on the etiology. Recent literature shows that optimal nutritional and medical support also plays an integral role in the management of pediatric patients with chronic cholestasis. This review will provide a broad overview of the pathophysiology, diagnostic approach, and management of cholestasis beyond the neonatal and infancy periods.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalPediatric Gastroenterology, Hepatology and Nutrition
Volume19
Issue number1
DOIs
StatePublished - Mar 1 2016

Keywords

  • Alagille syndrome
  • Biliary cysts
  • Cholelithiasis
  • Cholestasis
  • Conjugated hyperbilirubinemia
  • Hepatitis
  • Hepatolenticular degeneration
  • Jaundice
  • Pruritus

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hepatology
  • Gastroenterology

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