Cholera in Lima, Peru, correlates with prior isolation of Vibrio cholerae from the environment

Augusto A. Franco, Alan D. Fix, Ana Prada, Eva Paredes, Juan C. Palomino, Anita C. Wright, Judith A. Johnson, Robert McCarter, Humberto Guerra, J. Glenn Morris

    Research output: Contribution to journalArticle

    Abstract

    The authors utilized a recently developed DNA probe technique to obtain quantitative data on occurrence of Vibrio cholerae in samples collected monthly from 12 environmental sites in Lima, Peru, from November 1993 through March 1995. Peak V. cholerae counts ranged from 102/ml to 105/ml, with the highest counts in sewage-contaminated areas and irrigation water. With our methodology, no V. cholerae cases were detected at any site during the winter months of July through October. Counts were detectable in the environment before onset of cholera in the community, with counts at 'cleaner' sites upriver correlating significantly with occurrence of community disease 2 and 3 months later. In sites with heavy sewage contamination, V. cholerae could still be detected before the onset of cases in the community; however, in contrast to upriver sites, counts at these latter sites correlated most closely with the number of concurrently occurring cholera cases. These data support a model of cholera seasonality in which initial increases in number of V. cholerae in the environment (possibly triggered by temperature) are followed by onset of illness in the community, with these human cases further amplifying the organism as the epidemic cycle proceeds.

    Original languageEnglish (US)
    Pages (from-to)1067-1075
    Number of pages9
    JournalAmerican journal of epidemiology
    Volume146
    Issue number12
    DOIs
    StatePublished - Jan 1 1997

    Keywords

    • Cholera
    • Environment
    • Vibrio cholerae

    ASJC Scopus subject areas

    • Epidemiology

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  • Cite this

    Franco, A. A., Fix, A. D., Prada, A., Paredes, E., Palomino, J. C., Wright, A. C., Johnson, J. A., McCarter, R., Guerra, H., & Glenn Morris, J. (1997). Cholera in Lima, Peru, correlates with prior isolation of Vibrio cholerae from the environment. American journal of epidemiology, 146(12), 1067-1075. https://doi.org/10.1093/oxfordjournals.aje.a009235