Cholera in Lima, Peru, correlates with prior isolation of Vibrio cholerae from the environment

Augusto A. Franco, Alan D. Fix, Ana Prada, Eva Paredes, Juan C. Palomino, Anita C. Wright, Judith A. Johnson, Robert McCarter, Humberto Guerra, J. Glenn Morris

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

The authors utilized a recently developed DNA probe technique to obtain quantitative data on occurrence of Vibrio cholerae in samples collected monthly from 12 environmental sites in Lima, Peru, from November 1993 through March 1995. Peak V. cholerae counts ranged from 102/ml to 105/ml, with the highest counts in sewage-contaminated areas and irrigation water. With our methodology, no V. cholerae cases were detected at any site during the winter months of July through October. Counts were detectable in the environment before onset of cholera in the community, with counts at 'cleaner' sites upriver correlating significantly with occurrence of community disease 2 and 3 months later. In sites with heavy sewage contamination, V. cholerae could still be detected before the onset of cases in the community; however, in contrast to upriver sites, counts at these latter sites correlated most closely with the number of concurrently occurring cholera cases. These data support a model of cholera seasonality in which initial increases in number of V. cholerae in the environment (possibly triggered by temperature) are followed by onset of illness in the community, with these human cases further amplifying the organism as the epidemic cycle proceeds.

Original languageEnglish (US)
Pages (from-to)1067-1075
Number of pages9
JournalAmerican journal of epidemiology
Volume146
Issue number12
DOIs
StatePublished - 1997
Externally publishedYes

Keywords

  • Cholera
  • Environment
  • Vibrio cholerae

ASJC Scopus subject areas

  • Epidemiology

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