Cholangiocarcinoma: Epidemiology, risk factors, pathogenesis, and diagnosis

Halim Charbel, Firas Al Kawas

Research output: Contribution to journalArticle

Abstract

Cholangiocarcinoma (CCA) is a rare tumor arising from the epithelium of the intrahepatic or the extrahepatic bile ducts. It is rarely diagnosed before 40 years of age except in patients with primary sclerosing cholangitis. CCA is usually clinically silent until the tumor obstructs the bile ducts. Carbohydrate antigen 19-9 is the most commonly used tumor marker, and magnetic resonance cholangiopancreatography is the best available imaging modality for CCA. Endoscopic retrograde cholangiopancreatography and cholangioscopy allow tissue acquisition. Positron emission tomography may play a role in identifying occult metastases. Tissue diagnosis is obtained by brush cytology or bile duct biopsy.

Original languageEnglish (US)
Pages (from-to)182-187
Number of pages6
JournalCurrent Gastroenterology Reports
Volume13
Issue number2
DOIs
StatePublished - Apr 2011
Externally publishedYes

Fingerprint

Cholangiocarcinoma
Epidemiology
Bile Ducts
Magnetic Resonance Cholangiopancreatography
Extrahepatic Bile Ducts
Sclerosing Cholangitis
Endoscopic Retrograde Cholangiopancreatography
Tumor Biomarkers
Positron-Emission Tomography
Cell Biology
Neoplasms
Epithelium
Carbohydrates
Neoplasm Metastasis
Biopsy
Antigens

Keywords

  • Biliary
  • Cholangiocarcinoma
  • Endoscopic retrograde cholangiopancreatography
  • Klatskin tumor

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Cholangiocarcinoma : Epidemiology, risk factors, pathogenesis, and diagnosis. / Charbel, Halim; Al Kawas, Firas.

In: Current Gastroenterology Reports, Vol. 13, No. 2, 04.2011, p. 182-187.

Research output: Contribution to journalArticle

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