Chloroquine stimulates absorption and inhibits secretion of ileal water and electrolytes.

R. Fogel, G. W. Sharp, Mark Donowitz

Research output: Contribution to journalArticle

Abstract

The effects of chloroquine diphosphate, a drug with "'membrane-stabilizing" properties, were studied on basal ileal absorption and on ileal secretion induced by increased intracellular cAMP levels and calcium (serotonin). The studies were performed on rat (in vivo) and rabbit ileum (in vitro). Intraluminal chloroquine (10(-4) M) reversed cholera toxin- and theophylline-induced secretion in rat ileum but did not alter the cholera toxin- and theophylline-induced increases in cAMP content. Addition of chloroquine (10(-4) M) to the mucosal surface of rabbit ileum did not alter basal active electrolyte transport or the serotonin-induced decreased Na and Cl absorption but inhibited the theophylline-induced C1 secretion. Addition of chloroquine (10(-4)) M) to the serosal surface stimulated net Na and Cl absorption. This effect may involve intracellular calcium. Chloroquine increased the rabbit ileal calcium content and decreased 45Ca2+ influx from the serosal surface. Both the mucosal and serosal effects of chloroquine described led to a net increase in absorptive function of the intestine and should prove useful in developing treatment of diarrheal diseases.

Original languageEnglish (US)
JournalThe American journal of physiology
Volume243
Issue number2
StatePublished - Aug 1982
Externally publishedYes

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Chloroquine
Electrolytes
Theophylline
Ileum
Water
Cholera Toxin
Rabbits
Calcium
Serotonin
Active Biological Transport
Intestines
Membranes
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)

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Chloroquine stimulates absorption and inhibits secretion of ileal water and electrolytes. / Fogel, R.; Sharp, G. W.; Donowitz, Mark.

In: The American journal of physiology, Vol. 243, No. 2, 08.1982.

Research output: Contribution to journalArticle

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